Genetic variants in BDNF ( rs6265 and rs11030119 ) and stroke susceptibility: a case-control analysis in South India.
| Autor: | Muraleedharan Nair A; Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India., Ramamoorthi C; Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India., Arumugam Senthilkumar M; Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India., Kanniyapillai R; Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India., Chandra Sekar PK; Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India., Rehman Syed Rasheed AH; Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India., Kannaian S; Department of Neurology, Chettinad Super Speciality Hospital, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India., Veerabathiran R; Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India. |
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| Jazyk: | angličtina |
| Zdroj: | Annals of human biology [Ann Hum Biol] 2024 Feb; Vol. 51 (1), pp. 2415984. Date of Electronic Publication: 2024 Nov 04. |
| DOI: | 10.1080/03014460.2024.2415984 |
| Abstrakt: | Background: Stroke occurs when the blood supply to part of the cerebral cortex is blocked, depriving it of oxygen and glucose, leading to cell death. It is a multifactorial disorder influenced by genetic, vascular, and environmental factors. Aim: This study investigated the association between two polymorphisms of the brain-derived neurotrophic factor (BDNF) gene, rs6265 and rs11030119 , and stroke risk in a South Indian population. Subjects and Methods: The study included 163 stroke cases and 160 healthy controls. Genomic DNA was extracted, and genotyping of rs6265 and rs11030119 polymorphisms was done using ARMS-PCR. Allelic and genotype frequencies were calculated, and odds ratios (OR) with 95% confidence intervals (CI) were determined using SPSS version 21.0. Results: The rs6265 polymorphism was significantly associated with stroke risk, with the GG genotype more frequent in controls (OR 1.79, 95% CI 1.05-1.76, p = 0.01). The rs11030119 polymorphism showed a positive association, with the AA genotype more prevalent in cases (OR 2.70, 95% CI 1.34-5.44, p = 0.003). Conclusion: This study suggests an association between BDNF polymorphisms ( rs6265 , rs1103011 9) and stroke risk in a South Indian population. Further research in larger populations is necessary to confirm these findings and explore the mechanisms involved. |
| Databáze: | MEDLINE |
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