High Prevalence of Carbapenem-resistant Klebsiella Pneumoniae in Fecal and Water Samples in Dhaka, Bangladesh.

Autor:	Kar S; Institute for developing Science and Health initiatives, Dhaka, Bangladesh., Kawser Z; Institute for developing Science and Health initiatives, Dhaka, Bangladesh., Sridhar S; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts  USA.; Harvard Medical School, Boston, Massachusetts  USA., Mukta SA; Institute for developing Science and Health initiatives, Dhaka, Bangladesh., Hasan N; Institute for developing Science and Health initiatives, Dhaka, Bangladesh., Siddik AB; Institute for developing Science and Health initiatives, Dhaka, Bangladesh., Habib MT; Institute for developing Science and Health initiatives, Dhaka, Bangladesh., Slater DM; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts  USA.; Harvard Medical School, Boston, Massachusetts  USA.; Massachusetts General Hospital for Children, Boston, Massachusetts  USA., Earl AM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts  USA., Worby CJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts  USA., Azad K; Institute for developing Science and Health initiatives, Dhaka, Bangladesh., Shamsuzzaman SM; Dhaka Medical College and Hospital, Dhaka, Bangladesh., Tanni NN; Dhaka Medical College and Hospital, Dhaka, Bangladesh., Khan RT; Institute for developing Science and Health initiatives, Dhaka, Bangladesh., Moonmoon M; Dhaka Medical College and Hospital, Dhaka, Bangladesh., Qadri F; Institute for developing Science and Health initiatives, Dhaka, Bangladesh.; International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh., Harris JB; Harvard Medical School, Boston, Massachusetts  USA.; Massachusetts General Hospital for Children, Boston, Massachusetts  USA., LaRocque RC; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts  USA.; Harvard Medical School, Boston, Massachusetts  USA.
Jazyk:	angličtina
Zdroj:	Open forum infectious diseases [Open Forum Infect Dis] 2024 Oct 11; Vol. 11 (11), pp. ofae612. Date of Electronic Publication: 2024 Oct 11 (Print Publication: 2024).
DOI:	10.1093/ofid/ofae612
Abstrakt:	We evaluated Klebsiella pneumoniae (Kp) gut carriage in healthy, unrelated adults and children living in separate households in Dhaka, Bangladesh. Average Kp prevalence in stool samples ranged from 61% in young children (15/25) to 81% in adults (21/26), with significantly higher abundance in adults ( P = .03, t -test). Kp was also prevalent in household water (64%, 21/33) and standing water (85%, 23/27). The presence of Kp in household water was not strongly linked to stool Kp abundance among household members. Antimicrobial resistance was notable: 9% (6/69) of stool and 16% (7/44) of water isolates exhibited multidrug resistance. Carbapenem resistance was observed in 12% of stool isolates (8/69) and 14% of water isolates (6/44). These findings underscore the commonality of Kp in human and environmental reservoirs in Dhaka, Bangladesh, and highlight the emergence of drug-resistant Kp beyond healthcare settings. Competing Interests: Potential Conflict of interest. J.B.H. and R.C.L. have received royalties from UpToDate. All other authors report no potential conflicts. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze:	MEDLINE
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