Performance of self-performed SARS-CoV-2 rapid antigen test: a systematic review and meta-analysis.

Autor:	Cai P; Department of Anatomy and Histology, School of Preclinical Medicine, Chengdu University, Chengdu, Sichuan, China., Wang J; Department of Anatomy and Histology, School of Preclinical Medicine, Chengdu University, Chengdu, Sichuan, China.; Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China., Ye P; Department of Anatomy and Histology, School of Preclinical Medicine, Chengdu University, Chengdu, Sichuan, China., Zhang Y; The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shannxi, China., Wang M; Department of Anatomy and Histology, School of Preclinical Medicine, Chengdu University, Chengdu, Sichuan, China., Guo R; Department of Pediatrics, Zhongshan Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China., Zhao H; Department of Pediatrics, Zhongshan Hospital of Xiamen University, Xiamen University, Xiamen, Fujian, China.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2024 Oct 18; Vol. 12, pp. 1402949. Date of Electronic Publication: 2024 Oct 18 (Print Publication: 2024).
DOI:	10.3389/fpubh.2024.1402949
Abstrakt:	Background: The aim of this study was to investigate the accuracy of self-tested SARS-CoV-2 rapid antigen tests. Methods: Databases of Pubmed, Embase, and Cochrane Library were searched for original studies investigating accuracy of self-tested SARS-CoV-2 rapid antigen tests, with RT-PCR as "gold standard." Results: Forty-five eligible studies were found after database searching and screening using pre-defined criteria. The accuracy results from 50,897 suspected COVID-19 patients were pooled, and the overall sensitivity, specificity and diagnostic odds ratio were 0.77, 1.00, and 625.95, respectively. Subgroup analysis showed higher sensitivity of rapid antigen tests in subgroups of Abbott Panbio, self-collected nasal swab samples, and use of nasopharyngeal or oropharyngeal swab and lower Ct cutoff value in RT-PCR. Conclusion: Fully self-performed SARS-CoV-2 rapid antigen tests showed overall high accuracy compared to "gold standard," and are reliable surrogates for the standard test of COVID-19 using nasopharyngeal or oropharyngeal samples and RT-PCR. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Cai, Wang, Ye, Zhang, Wang, Guo and Zhao.)
Databáze:	MEDLINE
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