Melatonin's role in the timing of sleep onset is conserved in nocturnal mice.

Autor: Kim P; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD Australia., Garner N; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD Australia., Tatkovic A; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD Australia., Parsons R; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD Australia.; Present Address: Australian Centres for Health Services Innovation and Healthcare Transformation, School of Public Health and Social Work, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD Australia., Chunduri P; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD Australia., Vukovic J; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD Australia.; Queensland Brain Institute, University of Queensland, Brisbane, QLD Australia., Piper M; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD Australia.; Queensland Brain Institute, University of Queensland, Brisbane, QLD Australia., Pfeffer M; Institute of Anatomy 2, Faculty of Medicine, Heinrich Heine University, Düsseldorf, Germany., Weiergräber M; Experimental Neuropsychopharmacology, Federal Institute for Drugs and Medical Devices, Bonn, Germany., Oster H; Institute of Neurobiology, Center of Brain, Behavior & Metabolism, University of Lübeck, Lübeck, Germany., Rawashdeh O; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, Brisbane, QLD Australia.
Jazyk: angličtina
Zdroj: Npj biological timing and sleep [NPJ Biol Timing Sleep] 2024; Vol. 1 (1), pp. 13. Date of Electronic Publication: 2024 Nov 01.
DOI: 10.1038/s44323-024-00013-1
Abstrakt: Melatonin supplementation strengthens non-restorative sleep rhythms and its temporal alignment in both humans and night-active rodents. Of note, although the sleep cycle is reversed in day-active and night-active (nocturnal) mammals, both, produce melatonin at night under the control of the circadian clock. The effects of exogenous melatonin on sleep and sleepiness are relatively clear, but its endogenous role in sleep, particularly, in timing sleep onset (SO), remains poorly understood. We show in nocturnal mice that the increases in mid-nighttime sleep episodes, and the mid-nighttime decline in activity, are coupled to nighttime melatonin signaling. Furthermore, we show that endogenous melatonin modulates SO by reducing the threshold for wake-to-sleep transitioning. Such link between melatonin and SO timing may explain phenomena such as increased sleep propensity in circadian rhythm sleep disorders and chronic insomnia in patients with severely reduced nocturnal melatonin levels. Our findings demonstrate that melatonin's role in sleep is evolutionarily conserved, effectively challenging the argument that melatonin cannot play a major role in sleep regulation in nocturnal mammals, where the main activity phase coincides with high melatonin levels.
Competing Interests: Competing interestsThe authors declare no competing interests.
(© The Author(s) 2024.)
Databáze: MEDLINE
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