SARS-CoV-2 seroprevalence screening study of a children's hospital health care workers.

Autor:	Pluss O; Center for Global Health, Colorado School of Public Health, Aurora, CO, USA., Berman S; Center for Global Health, Colorado School of Public Health, Aurora, CO, USA.; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA., Lamb M; Center for Global Health, Colorado School of Public Health, Aurora, CO, USA.; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA., Knight V; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA., Roell Y; Center for Global Health, Colorado School of Public Health, Aurora, CO, USA., Berkowitz S; Department of Psychiatry and Pediatrics, University of Colorado, School of Medicine, Aurora, CO, USA., Jaenisch T; Center for Global Health, Colorado School of Public Health, Aurora, CO, USA.; Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, USA.
Jazyk:	angličtina
Zdroj:	Journal of infection prevention [J Infect Prev] 2024 Nov; Vol. 25 (6), pp. 206-213. Date of Electronic Publication: 2024 Apr 14.
DOI:	10.1177/17571774241245260
Abstrakt:	Background: Health care workers (HCWs) are front line responders to the COVID-19 pandemic, but limited data is available for pediatric HCWs, as the research response has largely focused on adult patients and medical personnel that treat these patients. Methods: We conducted a cross-sectional study of SARS-CoV-2 seroprevalence and risk factors in HCWs at a Children's Hospital in CO, USA from September 2020 to April 2021. Pediatric HCWs were defined as clinical care providers and administrative staff. Seroprevalence was determined using the Epitope SARS-CoV-2 anti-Nucleocapsid IgG assay (San Diego, CA) and the Euroimmun SARS-CoV-2 anti-Spike Protein IgG assay. Risk factors and vaccination status were assessed via questionnaire. Results: Overall, 110 HCWs were enrolled, 79 subjects were positive for anti-S antibodies and negative for anti-N antibodies, indicating COVID-19 vaccination. 31 subjects had neither anti-N or anti-S antibodies, indicating no exposure to SARS-CoV-2 and no vaccination. 3/110 had a nucleocapsid serology consistent with a SARS-CoV-2 prior infection. Seroprevalence was observed at 2.7%. It was noted that asthma requiring medication was associated with positive serostatus. Conclusions: During the winter 2020/21, SARS-CoV-2, we found a 2.7% seroprevalence of pediatric HCW at a children's hospital in Colorado. We compared this with publicly available seroprevalence data for seroprevalence rates of pediatric HCWs globally. This suggests that this specific children's hospital COVID-19 personal protective equipment (PPE) and infection control guidelines were effective in limiting SARS-CoV-2 in hospital transmission at the children's hospital prior to the presence of the Delta variant. Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. (© The Author(s) 2024.)
Databáze:	MEDLINE
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