Recurrent Thrombosis in a Very Elderly Patient With Dementia, Atrial Fibrillation, and Idiopathic Thrombocytopenic Purpura on Eltrombopag Treatment.

Autor:	Kurisu S; Department of Cardiology, National Hospital Organization Hiroshima-Nishi Medical Center, Otake, JPN., Fujiwara H; Department of Cardiology, National Hospital Organization Hiroshima-Nishi Medical Center, Otake, JPN., Shimomura T; Department of Haematology, National Hospital Organization Hiroshima-Nishi Medical Center, Otake, JPN.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Oct 03; Vol. 16 (10), pp. e70792. Date of Electronic Publication: 2024 Oct 03 (Print Publication: 2024).
DOI:	10.7759/cureus.70792
Abstrakt:	Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder, leading to an increased bruising and bleeding tendency. Eltrombopag, a thrombopoietin receptor agonist, is an effective treatment option even in elderly patients with ITP. In this report, we present a case of recurrent thrombosis, presenting as acute myocardial infarction and cerebral infarction, in a very elderly patient with dementia, atrial fibrillation, and ITP on eltrombopag treatment. Multiple comorbidities with thrombosis and bleeding risks posed a therapeutic dilemma. Conditions unique to the elderly, such as cognitive impairment or frailty, led to a delayed diagnosis. This case gives an insight into how to manage a practical therapeutic problem in such a case. Physicians need to understand conditions unique to the elderly, such as cognitive impairment, frailty, or quality of life that influence treatment goals. These efforts can help provide health benefits while minimizing treatment risks, especially in elderly patients with multiple comorbidities. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Kurisu et al.)
Databáze:	MEDLINE
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