Remineralization Effect of Bioactive Glass With and Without Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) on Artificial Dentine Caries: An In Vitro Study.

Autor:	Manzoor K; Dental Biomaterials, Islamic International Dental College, Islamabad, PAK., Manzoor S; Dental Biomaterials, Islamic International Dental College, Islamabad, PAK., Qazi Z; Dental Biomaterials, Islamic International Dental College, Islamabad, PAK., Ghaus S; Dental Biomaterials, Islamic International Dental College, Islamabad, PAK., Saleem M; Dental Biomaterials, Bakhtawar Amin Medical and Dental College, Multan, PAK., Kashif M; Oral Pathology, Bakhtawar Amin Medical and Dental College, Multan, PAK.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Oct 03; Vol. 16 (10), pp. e70801. Date of Electronic Publication: 2024 Oct 03 (Print Publication: 2024).
DOI:	10.7759/cureus.70801
Abstrakt:	Background/objectives Dentine hypersensitivity (DH) is a common dental condition marked by transient, sharp pain arising from dentinal exposure. Bioactive materials are capable of remineralization. This study aims to explore the remineralization effect of bioactive glass (BAG) with and without fluoride and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), using dentine discs as the test substrate. Materials and methods In this in vitro experimental study, 28 dentine discs were prepared from premolar teeth. Artificial caries were induced by subjecting the dentine discs to demineralization in acid for 72 hours. After demineralization, the discs were treated with various remineralizing dentifrices to evaluate their effects. The dentine discs (n=28) were divided into four groups: group 1 = BioMin (BioMin Technologies, London, United Kingdom), group 2 = NovaMin/Sensodyne Repair (GlaxoSmithKline plc, London, England, United Kingdom), group 3 = Recaldent (CPP-ACP; GC Orthodontics Inc., Alsip, Illinois, United States), and group 4 = deionized water (control group). All discs underwent a 28-day remineralization process using the respective dentifrices assigned to each group. The microhardness of the discs was measured using Vickers microhardness testing at three stages: baseline, post-demineralization, and post-remineralization. Results There was no significant difference in terms of microhardness between groups both at the baseline (F (3, 24) = 1.079, p = 0.995) and after the demineralization process (F (3, 24) = 1.310, p = 0.294). However, a significant difference was identified between the groups after the remineralization process (F (3, 24) = 34.008, p = 0.001). Additionally, the least significant difference (LSD) multiple comparison test was performed. There were significant differences identified in the remineralization condition, with group 1 having the highest values, followed by group 2, group 3, and group 4. Conclusion The results indicate that the remineralization effect on artificially induced dentine caries was more pronounced with bioactive glass containing fluoride compared to bioactive glass without fluoride and CPP-ACP. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Ethics Committee of the Islamic Dental College, Riphah University, Islamabad, issued approval IIDC/IRC/2022/012/007. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Manzoor et al.)
Databáze:	MEDLINE
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