Prognostic impact of age on outcomes of hepatic decompensation in patients with compensated cirrhosis (CHESS2102): an international, multicenter cohort study.

Autor: Liu S; Liver Disease Center of Integrated Traditional Chinese and Western Medicine Department of Radiology Zhongda Hospital Medical School Southeast University Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China.; Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital, Southeast University State Key Laboratory of Digital Medical Engineering Nanjing China., Li J; Department of Gastroenterology and Hepatology Tianjin Second People's Hospital Tianjin China., Wong Y; Department of Gastroenterology & Hepatology Changi General Hospital SingHealth Singapore Singapore.; Duke-NUS Medical School Singapore Singapore., Yim HJ; Division of Gastroenterology and Hepatology Korea University Ansan Hospital Ansan Gyeonggi Republic of Korea., Hirooka M; Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Ehime Japan., Enomoto H; Division of Hepatobiliary and Pancreatic Diseases Department of Gastroenterology Hyogo Medical University Nishinomiya Japan., Xie Q; Department of Infectious Disease Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China., Dai E; Division of Liver Diseases The Fifth Hospital of Shijiazhuang North China University of Science and Technology Shijiazhuang China., Hanafy AS; Division of Gastroenterology Hepatology and Endoscopy Internal Medicine Zagazig University Faculty of Medicine Zagazig Egypt., Cao Z; Department of Infectious Disease Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China., Zhao L; Department of Gastroenterology and Hepatology Tianjin Second People's Hospital Tianjin China., Teh KB; Department of Gastroenterology & Hepatology Changi General Hospital SingHealth Singapore Singapore.; Duke-NUS Medical School Singapore Singapore., Kim TH; Division of Gastroenterology and Hepatology Korea University Ansan Hospital Ansan Gyeonggi Republic of Korea.; Division of Gastroenterology and Hepatology Hallym University Sacred Heart Hospital Anyang Gyeonggi Republic of Korea., Jung YK; Division of Gastroenterology and Hepatology Korea University Ansan Hospital Ansan Gyeonggi Republic of Korea., Koizumi Y; Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Ehime Japan., Hiasa Y; Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine Ehime Japan., Nishimura T; Department of Internal Medicine Division of Gastroenterology and Hepatology Hyogo Medical University Nishinomiya Japan.; Ultrasound Imaging Center Hyogo Medical University Nishinomiya Japan., Iijima H; Department of Internal Medicine Division of Gastroenterology and Hepatology Hyogo Medical University Nishinomiya Japan.; Ultrasound Imaging Center Hyogo Medical University Nishinomiya Japan., Tian Q; Liver Disease Center of Integrated Traditional Chinese and Western Medicine Department of Radiology Zhongda Hospital Medical School Southeast University Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China., Guo X; Division of Liver Diseases The Fifth Hospital of Shijiazhuang North China University of Science and Technology Shijiazhuang China., Jia Y; Division of Liver Diseases The Fifth Hospital of Shijiazhuang North China University of Science and Technology Shijiazhuang China., Sun J; Department of Epidemiology and Biostatistics School of Public Health Southeast University Nanjing China.; Key Laboratory of Environmental Medicine Engineering Ministry of Education School of Public Health Southeast University Nanjing China., Liu C; Liver Disease Center of Integrated Traditional Chinese and Western Medicine Department of Radiology Zhongda Hospital Medical School Southeast University Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China.; Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital, Southeast University State Key Laboratory of Digital Medical Engineering Nanjing China., Qi X; Liver Disease Center of Integrated Traditional Chinese and Western Medicine Department of Radiology Zhongda Hospital Medical School Southeast University Nurturing Center of Jiangsu Province for State Laboratory of AI Imaging & Interventional Radiology (Southeast University) Nanjing China.; Basic Medicine Research and Innovation Center of Ministry of Education Zhongda Hospital, Southeast University State Key Laboratory of Digital Medical Engineering Nanjing China.
Jazyk: angličtina
Zdroj: MedComm [MedComm (2020)] 2024 Nov 03; Vol. 5 (11), pp. e781. Date of Electronic Publication: 2024 Nov 03 (Print Publication: 2024).
DOI: 10.1002/mco2.781
Abstrakt: Baveno VII criteria (B7C) and Baveno VI criteria (B6C) have been widely used to estimate the risk of hepatic decompensation. However, the impact of age on these criteria warrants further investigation. The international, multicenter cohort study included 1138 patients with compensated cirrhosis (median follow-up of 40.6 months), aiming to evaluate the value of age in predicting hepatic decompensation. We identified age as an independent predictor of hepatic decompensation, with 60 years determined as the optimal cut-off value. The occurrence of decompensation was 18.7% and 6.7% in the older (age ≥60 years) and younger (age <60 years) groups, respectively ( p  < 0.001). We subsequently integrated age into the existing Baveno criteria. In patients not meeting Baveno criteria (defined as not meeting B6C or B7C), the older group exhibited a significantly elevated risk of decompensation compared to the younger group ( p  < 0.05). However, no significant difference was observed between the older and younger groups in patients meeting Baveno criteria ( p  > 0.05). In conclusion, our study demonstrated that integrating age into the Baveno criteria could enhance the assessment of hepatic decompensation. Age should be considered before discharging patients with compensated cirrhosis from the surveillance of hepatic decompensation.
Competing Interests: All authors declare no conflicts of interest.
(© 2024 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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