Exploration of One-Pot, Tandem Sulfamoylation and aza -Michael Cyclization Reactions for the Syntheses of Oxathiazinane Dioxide Heterocycles.
| Autor: | Nirpal AK; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States., Joshi H; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States., Kelley SP; Department of Chemistry, University of Missouri─Columbia, Columbia, Missouri 65211, United States., Sathyamoorthi S; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of organic chemistry [J Org Chem] 2024 Nov 15; Vol. 89 (22), pp. 16774-16778. Date of Electronic Publication: 2024 Nov 04. |
| DOI: | 10.1021/acs.joc.4c02086 |
| Abstrakt: | We show the first examples of one-pot tandem sulfamoylation/ aza -Michael reactions for the preparation of oxathiazinane dioxide heterocycles from linear alkenyl alcohol precursors. Our optimized protocols are tolerant of a variety of functional groups and provide products that are amenable for further transformations. The reactions scale well, and no special precautions are required to exclude air or ambient moisture. |
| Databáze: | MEDLINE |
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