Associations between BCL-2 expression and different histopathological prognostic factors in different molecular subtypes of invasive breast carcinoma of no special type.

Autor:	Hassan WA; Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. w.hassan@sr.edu.sa.; Department of Basic Sciences, Faculty of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah, Saudi Arabia., El-Assmy M; Department of Clinical Sciences, Sulaiman Al Rajhi University, Al Bukayriyah, Saudi Arabia., ElBanna AK; Department of Basic Sciences, Faculty of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah, Saudi Arabia.; Department of Anatomy, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Harbieh I; Department of Basic Sciences, Faculty of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah, Saudi Arabia., Noufal N; Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.; Department of Basic Medical Sciences, College of Medicine, Dar Al Uloom University, Riyadh, Saudi Arabia., Lotfy H; Department of Basic Sciences, Faculty of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah, Saudi Arabia.; Department of Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Shemais TAH; Department of Basic Sciences, Faculty of Medicine, Sulaiman Al Rajhi University, Al Bukayriyah, Saudi Arabia.; Medical Biochemistry Department, Faculty of Medicine, Al-Azhar University, New Damietta, Egypt., Haikal OA; Department of Clinical Sciences, Sulaiman Al Rajhi University, Al Bukayriyah, Saudi Arabia., Saber MM; Medical Oncology Department, Faculty of Medicine, Port Said University, Egypt., Ali RI; Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.; Department of Pathology, College of Medicine, Jouf University, Al-Jawf, Saudi Arabi.
Jazyk:	angličtina
Zdroj:	Histology and histopathology [Histol Histopathol] 2024 Oct 11, pp. 18831. Date of Electronic Publication: 2024 Oct 11.
DOI:	10.14670/HH-18-831
Abstrakt:	Background: Breast cancer is heterogeneous and the existing prognostic classifiers are limited in accuracy, leading to the unnecessary treatment of numerous women. B-cell lymphoma 2 (BCL-2), an anti-apoptotic protein, has been proposed as a marker of poor prognosis, associated with resistance to therapy in most tumor types expressing BCL-2. In breast cancer, however, BCL-2 expression has been reported to be a favorable prognostic factor. This study aimed to describe the association between BCL-2 and other well-known pathological prognostic markers among different molecular sub-types of invasive breast carcinoma of no special type (IBC; NST). Methods: BCL-2 expression, as well as that of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), were immunohistochemically (IHC) evaluated and compared with other pathological factors, including tumor size, grade, tumor-infiltrating lymphocytes (TILs), lymph-vascular invasion (LVI), and lymph node (LNd) metastasis, in 128 breast cancer cases diagnosed with IBC; NST. Moreover, we analyzed the correlation between BCL-2 expression and relapse-free survival (RFS) in all patients over a two-year period. Results: We found that BCL-2 expression had different pathological prognostic factor associations with different molecular subtypes of breast carcinoma. In the luminal A (i.e., hormonal receptor-positive and HER2-negative) and triple-negative subtypes, the expression of BCL-2 in tumor cells was significantly associated with tumor size, tumor grade, and TILs. BCL2-positive expression in luminal IBC; NST patients resulted in a significantly favorable two-year survival. Conclusion: BCL-2 expression in IBC; NST has different prognostic effects depending on the molecular subtype of the cancer. In cancers with a HER2-enriched phenotype, BCL-2 expression was a marker of poor prognosis, while in cancers with a hormone receptor-positive phenotype, BCL-2 expression had a better prognostic impact. (©The Author(s) 2024. Open Access. This article is licensed under a Creative Commons CC-BY International License.)
Databáze:	MEDLINE
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