Cancer mortality among solid organ transplant recipients: A systematic review and meta-analysis.

Autor: Wang Z; Institute of Transplantation Medicine, Tianjin First Central Hospital, Nankai University, Tianjin 300192, China., Deng L; Institute of Preventive Medicine, Tianjin Centers for Disease Control and Prevention, Tianjin 310011, China., Hou W; Institute of Transplantation Medicine, Tianjin First Central Hospital, Nankai University, Tianjin 300192, China., Liu S; Institute of Transplantation Medicine, Tianjin First Central Hospital, Nankai University, Tianjin 300192, China., Zhang Y; Department of Epidemiology & Biostatistics, School of Public Health, Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin 300070, China., Sheng C; Department of Epidemiology and Biostatistics, Key Laboratory of Molecular Cancer Epidemiology, Tianjin, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China., Zhang Y; Department of Medical Oncology, Second Hospital of Tianjin Medical University, Tianjin 300211, China., Li J; Core Laboratory, Research Services Department, the University of Hong Kong-Shenzhen Hospital, Shenzhen 518040, China., Shen Z; Institute of Transplantation Medicine, Tianjin First Central Hospital, Nankai University, Tianjin 300192, China; Tianjin Key Laboratory for Organ Transplantation, Tianjin First Central Hospital, Tianjin 300192, China; Organ Transplantation Centre, Tianjin First Central Hospital, Tianjin 300192, China; Key Laboratory of Transplantation, Chinese Academy of Medical Sciences, Tianjin First Central Hospital, Tianjin 300192, China. Electronic address: zhongyangshen@nankai.edu.cn.
Jazyk: angličtina
Zdroj: Preventive medicine [Prev Med] 2024 Dec; Vol. 189, pp. 108161. Date of Electronic Publication: 2024 Nov 02.
DOI: 10.1016/j.ypmed.2024.108161
Abstrakt: Objectives: To evaluate the cancer mortality risk among solid organ transplant recipients through a systematic review and meta-analysis.
Methods: Systematic searches were conducted in PubMed (starting from 1965), ISI Web of Science (starting from 1900), MEDLINE (starting from 1976), and Scopus (starting from 1968) from the inception of each database until July 15, 2024. Studies published in English reporting at least one type of cancer mortality risk among recipients of any type of solid organ transplantation were included. The main outcomes were the standardized mortality ratio (SMR) for cancer mortality in transplant recipients compared to the general population, and the hazard ratio (HR) for cancer mortality in transplant recipients versus cancer patients without prior transplantation.
Results: Solid organ transplant recipients had a 2.06-fold increased cancer mortality risk (SMR, 2.06 [95 % CI, 1.56-2.71]) than the general population. Risks were higher in kidney (SMR 1.92 [95 % CI: 1.30-2.84]), liver (SMR 3.07 [95 % CI: 1.80-5.24]), and lung/heart (SMR 4.87 [95 % CI: 3.33-7.12]) transplant recipients. Cancer patients with prior transplantation had a 1.47-fold increased cancer mortality risk (HR 1.47 [95 % CI: 1.29-1.68]) than those without. East Asia female transplant recipients exhibited higher mortality risks from breast, ovarian, cervix and uterus cancers than those from other regions (SMR 3.13 [95 % CI: 1.93-5.07] vs. 1.16 [95 % CI: 0.88-1.53], P < 0.01).
Conclusions: Solid organ transplant recipients face significantly higher cancer mortality risks than the general population, highlighting the need for targeted cancer screening and interventions, especially for female solid organ transplant recipients from East Asia.
Competing Interests: Declaration of competing interest The authors declare that there is no conflict of interest.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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