FLASH radiotherapy using high-energy X-rays: Current status of PARTER platform in FLASH research.

Autor: Yang Y; Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900, China., Wang J; Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900, China., Gao F; Department of Oncology, NHC Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital), Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology, Mianyang 621000, China., Liu Z; Department of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Chengdu 610041, China., Dai T; Department of Oncology, NHC Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital), Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology, Mianyang 621000, China., Zhang H; School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou 215123, China., Zhu H; Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China., Wang T; Department of Oncology, NHC Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital), Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology, Mianyang 621000, China., Xiao D; Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900, China., Zhou K; Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900, China., Zhou Z; Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900, China., Wu D; Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900, China., Du X; Department of Oncology, NHC Key Laboratory of Nuclear Technology Medical Transformation (Mianyang Central Hospital), Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology, Mianyang 621000, China. Electronic address: duxiaobo2005@126.com., Bai S; Department of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: winfield1920@126.com.
Jazyk: angličtina
Zdroj: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2023 Oct 27, pp. 109967. Date of Electronic Publication: 2023 Oct 27.
DOI: 10.1016/j.radonc.2023.109967
Abstrakt: Purpose: Recent studies indicated that ultrahigh dose rate (FLASH) radiation can reduce damage to normal tissue while maintaining anti-tumour activity compared to conventional dose rate (CONV) radiation. This paper provides a comprehensive description of the current status of the Platform for Advanced Radiotherapy Research (PARTER), which serves as the first experimental FLASH platform utilizing megavoltage X-rays and has facilitated numerous experiments.
Methods and Materials: PARTER was established in 2019 based on a superconducting linac to support experimental FLASH studies using megavoltage X-rays. Continuous upgrades have been made to the accelerator, collimators, flattening filters, monitors, other auxiliary devices, and irradiation process in order to achieve optimal results. Passive and active dosimeters are employed for measuring dose distribution and to ensure traceability of radiation doses.
Results: The dose monitors and dosimeters demonstrate reliable performance with acceptable stability. At PARTER, the maximum mean dose rate is approximately 400 Gy/s at a surface-source distance of 20 cm (over 1000 Gy/s at smaller distances), with an instantaneous dose rate of approximately 8E5 Gy/s. Both passive and active dosimeters exhibit good linearity and agreement during FLASH X-ray irradiation. The monitors show good linearity to dose rate, with short-term fluctuations within 1.5% for the diamond monitor. The discrepancy between measured absorbed dose and dose protocol is typically less than 4%. The X-ray energy spectra on PARTER are comparable to those for megavoltage CONV linacs operating in flattening filter-free mode. The maximum field size of the FLASH beam is 4.5 cm × 4.5 cm. The FLASH dose profile demonstrates satisfactory flatness (1.04) and similar penumbra compared to clinical CONV linac, while the percentage depth dose curve of FLASH X-rays is steeper than that of the clinical megavoltage CONV X-ray.
Conclusions: PARTER represents a pioneering platform for conducting megavolts FLASH X-ray irradiation in biological experiments. It effectively fulfills the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades to meet increasingly demanding performance criteria.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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