The Banff 2022 Kidney Meeting Report: Re-Appraisal of Microvascular Inflammation and the Role of Biopsy-Based Transcript Diagnostics.

Autor:	Naesens M; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium. Electronic address: maarten.naesens@kuleuven.be., Roufosse C; Department of Immunology and Inflammation, Faculty Medicine, Imperial College London, London, UK. Electronic address: c.roufosse@imperial.ac.uk., Haas M; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Lefaucheur C; Université Paris Cité, INSERM, PARCC, Paris Institute for Transplantation and Organ Regeneration, France & Department of Nephrology and Transplantation, Saint-Louis Hospital, Paris, France., Mannon RB; Department of Internal Medicine, UNMC, Omaha, NE, USA., Adam BA; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada., Aubert O; Université Paris Cité, INSERM, PARCC, Paris Institute for Transplantation and Organ Regeneration, France & Department of Transplantation, Necker Hospital, Paris, France., Böhmig GA; Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Callemeyn J; Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium., Groningen MC; Department of Pathology and Clinical Bioinformatics, Erasmus University Center Rotterdam, Rotterdam, The Netherlands; Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany., Cornell LD; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Demetris AJ; UPMC Hepatic and Transplantation Pathology, Pittsburgh, PA, USA., Drachenberg CB; University of Maryland School of Medicine, Baltimore, MD, USA., Einecke G; Department of Nephrology and Rheumatology, University Medical Center Göttingen, Göttingen, Germany., Fogo AB; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Gibson IW; Department of Pathology, University of Manitoba, Winnipeg, Canada., Halloran P; Department of Medicine, Alberta Transplant Applied Genomics Centre, Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada., Hidalgo LG; Department of Surgery, University of Wisconsin, Madison, WI, USA., Horsfield C; Department of Histopathology, Guy's & St Thomas' Hospital, London, UK., Huang E; Department of Medicine, Division of Nephrology, Cedars-Sinai Medical Center, West Hollywood, CA, USA., Kikić Ž; Department of Urology, Medical University of Vienna, Vienna, Austria., Kozakowski N; Department of Pathology, Medical University of Vienna, Vienna, Austria., Nankivell B; Department of Renal Medicine, Westmead Hospital, Westmead, New South Wales, Australia., Rabant M; Pathology department, Necker-Enfants Malades Hospital, Paris, France., Randhawa P; Pathology, Thomas E. Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA, USA., Riella LV; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sapir-Pichhadze R; Division of Nephrology & Multi-Organ Transplant Program, McGill University, Montreal, Quebec, Canada., Schinstock C; Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA., Solez K; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada., Tambur AR; Comprehensive Transplant Center, Northwestern University, Chicago, IL, USA., Thaunat O; Department of Transplantation Nephrology and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France., Wiebe C; Department of Medicine and Department of Immunology, University of Manitoba, Winnipeg, Canada., Zielinski D; Université Paris Cité, INSERM, PARCC, Paris Institute for Transplantation and Organ Regeneration, France & Department of Transplantation, Necker Hospital, Paris, France., Colvin R; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Loupy A; Université Paris Cité, INSERM, PARCC, Paris Institute for Transplantation and Organ Regeneration, France & Department of Transplantation, Necker Hospital, Paris, France., Mengel M; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Canada.
Jazyk:	angličtina
Zdroj:	American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2023 Oct 27. Date of Electronic Publication: 2023 Oct 27.
DOI:	10.1016/j.ajt.2023.10.016
Abstrakt:	The XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark the 30 th anniversary of the first Banff Classification, pre-meeting discussions were held on the past, present, and future of the Banff Classification. This report is a summary of the meeting highlights that were most important in terms of their effect on the Classification, including discussions around microvascular inflammation and biopsy-based transcript analysis for diagnosis. In a post-meeting survey, agreement was reached on the delineation of the following phenotypes: (1) "Probable antibody-mediated rejection (AMR)", which represents DSA-positive cases with some histological features of AMR but below current thresholds for a definitive AMR diagnosis; and (2) "Microvascular inflammation (MVI), DSA-negative and C4d-negative", a phenotype of unclear cause requiring further study, which represents cases with MVI not explained by DSA. Although biopsy-based transcript diagnostics are considered promising and remain an integral part of the Banff Classification (limited to diagnosis of AMR), further work needs to be done to agree on the exact classifiers, thresholds, and clinical context of use. Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests (Copyright © 2023. Published by Elsevier Inc.)
Databáze:	MEDLINE
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