Blue light stimulation of the blind spot in human: from melanopsin to clinically relevant biomarkers of myopia.

Autor: Amorim-de-Sousa A; Clinical & Experimental Optometry Research Lab, Physics Center of Minho and Porto Universities, University of Minho, Braga, Portugal., Chakraborty R; Myopia and Visual Development Lab, Flinders University College of Nursing and Health Sciences, Bedford Park, South Australia, Australia., Collins MJ; Contact Lens and Visual Optics Laboratory, Centre for Vision and Eye Research, Optometry and Vision Science, Queensland University of Technology, Brisbane, Australia., Fernandes P; Clinical & Experimental Optometry Research Lab, Physics Center of Minho and Porto Universities, University of Minho, Braga, Portugal., González-Méijome J; Clinical & Experimental Optometry Research Lab, Physics Center of Minho and Porto Universities, University of Minho, Braga, Portugal., Hannibal J; Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Institute of Clinical Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark., Hoseini-Yazdi H; Contact Lens and Visual Optics Laboratory, Centre for Vision and Eye Research, Optometry and Vision Science, Queensland University of Technology, Brisbane, Australia., Read SA; Contact Lens and Visual Optics Laboratory, Centre for Vision and Eye Research, Optometry and Vision Science, Queensland University of Technology, Brisbane, Australia., Ellrich J; Dopavision GmbH, Pfuelstrasse 5, 10997, Berlin, Germany.; Medical Faculty, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany., Schilling T; Dopavision GmbH, Pfuelstrasse 5, 10997, Berlin, Germany. schilling@dopavision.com.
Jazyk: angličtina
Zdroj: Bioelectronic medicine [Bioelectron Med] 2024 Nov 04; Vol. 10 (1), pp. 26. Date of Electronic Publication: 2024 Nov 04.
DOI: 10.1186/s42234-024-00159-0
Abstrakt: The protective effects of time spent outdoors emphasize the major role of daylight in myopia. Based on the pathophysiology of myopia, the impact of blue light stimulation on the signaling cascade, from melanopsin at the blind spot to clinically relevant biomarkers for myopia, was investigated. Parameters and site of light stimulation are mainly defined by the photopigment melanopsin, that is sensitive to blue light with a peak wavelength of 480 nm and localized on the intrinsically photosensitive retinal ganglion cells (ipRGC) whose axons converge to the optic disc, corresponding to the physiological blind spot. Blue light at the blind spot (BluSpot) stimulation provides the opportunity to activate the vast majority of ipRGC and avoids additional involvement of rods and cones which may exert incalculable effects on the signaling cascade.Experimental studies have applied anatomical, histochemical, electrophysiological, imaging, and psychophysical methods to unravel the mode of action of BluSpot stimulation. Results indicate activation of melanopsin, improvement of contrast sensitivity, gain in electrical retinal activity, and increase of choroidal thickness following BluSpot stimulation. Short-term changes of clinically relevant biomarkers lead to the hypothesis that BluSpot stimulation may exert antimyopic effects with long-term application.
(© 2024. The Author(s).)
Databáze: MEDLINE
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