Impact of maternal health and stress on steroid hormone profiles in human milk: Implications for infant development.

Autor:	Ten-Doménech I; Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS-SAMID) (RD21/0012/0015), Instituto de Salud Carlos III, Madrid, Spain., Moreno-Giménez A; Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain; Mental Health Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain., Campos-Berga L; Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain; Mental Health Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain., Zapata de Miguel C; Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain; Mental Health Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain., López-Nogueroles M; Unidad Analítica, Health Research Institute La Fe (IISLAFE), Valencia, Spain., Parra-Llorca A; Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain; Division of Neonatology, University & Polytechnic Hospital La Fe, Valencia, Spain., Quintás G; Health and Biomedicine, Leitat Technological Center, Terrassa, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain., García-Blanco A; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS-SAMID) (RD21/0012/0015), Instituto de Salud Carlos III, Madrid, Spain; Mental Health Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain., Gormaz M; Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain; Division of Neonatology, University & Polytechnic Hospital La Fe, Valencia, Spain., Kuligowski J; Neonatal Research Group, Health Research Institute La Fe (IISLAFE), Valencia, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin Network (RICORS-SAMID) (RD21/0012/0015), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: julia.kuligowski@uv.es.
Jazyk:	angličtina
Zdroj:	Journal of lipid research [J Lipid Res] 2024 Oct 26; Vol. 65 (12), pp. 100688. Date of Electronic Publication: 2024 Oct 26.
DOI:	10.1016/j.jlr.2024.100688
Abstrakt:	Steroid hormones are biologically active factors in human milk (HM) that influence the physical and mental development of infants. Critically, maternal psychosocial stress has been associated with changes in HM steroid composition. This work aimed to characterize the steroid hormone profile of HM and pasteurized donor human milk (DHM) and assess the interplay between maternal physical and psychosocial status, the HM steroid profile, and infant outcomes. A targeted ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed to quantify sixteen steroid hormones in HM samples. HM samples from mothers of term infants (N = 42) and preterm infants (N = 35) were collected at (i) recovery of birth weight or achievement of complete enteral nutrition, respectively, and (ii) 6 months later as well as DHM samples (N = 19) from 11 donors. The physical and psychosocial status of mothers and infant neurodevelopment and temperament were assessed through structured interviews and validated questionnaires. Fourteen steroids were detected in HM/DHM samples, with cortisol, 20β-dihydrocortisol, dehydroepiandrosterone, pregnenolone, and cortisone being present in > 48% of samples. Pregnenolone, 17α-OH-progesterone, and dehydroepiandrosterone are reported for the first time in HM. Whereas milk cortisol levels were not directly related to maternal physical and psychosocial status nor with infant development, cortisone, and pregnenolone correlated positively with maternal weight gain during pregnancy and were associated with maternal well-being and infant growth. The pasteurization process may have a detrimental effect on the steroid hormone levels in HM, which might influence the development of receptors. Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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