Inhibitory effects of phenylpropionamides from the hemp seed husk on tyrosinase.

Autor: Kim JH; Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung, Chungbuk 27709, Republic of Korea., Han KS; Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung, Chungbuk 27709, Republic of Korea., Lee ES; Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung, Chungbuk 27709, Republic of Korea., Kim YG; Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung, Chungbuk 27709, Republic of Korea., Kim YI; Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung, Chungbuk 27709, Republic of Korea., Cheon JY; Department of Oriental Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Sinyong-dong, Iksan 570-749, Republic of Korea., Jung HJ; Department of Oriental Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Sinyong-dong, Iksan 570-749, Republic of Korea., Kim KM; KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. Electronic address: vsrc@kiom.re.kr., Lee IS; KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea. Electronic address: knifer48@kiom.re.kr.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Dec; Vol. 282 (Pt 2), pp. 136939. Date of Electronic Publication: 2024 Oct 28.
DOI: 10.1016/j.ijbiomac.2024.136939
Abstrakt: Tyrosinase is an enzyme involved in melanin production. To identify inhibitors of this enzyme in natural products, extracts and fractions of hemp seed husk were screened for tyrosinase inhibition. Phenylpropionamides 1-9, which were isolated from the ethyl acetate fraction, had inhibitory effects; compounds 3 and 4 had the greatest inhibitory effects. Cannabisin A (3) was a non-competitive and cannabisin B (4) was a competitive inhibitor. The binding sites and interactions of each inhibitor on tyrosinase were calculated by computational chemistry. Potential inhibitor 3 decreased the melanin content and tyrosinase activity in B16F10 melanoma cells. Therefore, cannabisin A (3) has potential as a tyrosinase inhibitor.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jang Hoon Kim reports administrative support was provided by Rural Development Administration.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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