The utilization of cytology for intraoperative diagnosis of primary central nervous system lymphoma.

Autor: Hu L; Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.; Department of Pathology, Binhai Campus of the First Affiliated Hospital, National Regional Medical Center, Fujian Medical University, Fuzhou, 350212, China., Tang J; Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China., Su X; Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China., Zheng L; Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China., Hu C; Fujian Medical University, Fuzhou, China., Wu Q; Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China., Lin X; Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou, China., Zeng S; Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China., Chen Y; Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China., Zhang S; Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China., Wang X; Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China. wang_xfu@126.com.; Department of Pathology, Binhai Campus of the First Affiliated Hospital, National Regional Medical Center, Fujian Medical University, Fuzhou, 350212, China. wang_xfu@126.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 03; Vol. 14 (1), pp. 26527. Date of Electronic Publication: 2024 Nov 03.
DOI: 10.1038/s41598-024-78187-8
Abstrakt: To investigate the diagnostic value of intraoperative cytology and rapid immunocytochemistry in primary central nervous system lymphoma. 254 cases of lymphoma and 82 cases of non-lymphoma were collected from 2010 to 2023. Frozen section(FS) was using alone in 44 cases during 2010-2014, FS and intraoperative cytology(IC) were using in 251 cases during 2015 to 2022. Rapid immunocytochemical(RICC, CD20, GFAP) were using with FS + IC in 41 cases during 2021 to 2023. Method One: According to the results of archives, statistic the diagnostic accuracy of lymphoma during three time periods. Method Two: All cases were randomly renumbered, 4 neuropathologists compared the accuracy of independent histology and that of combining cytology. The archives showed the diagnostic accuracy of FS in PCNSL was 77.27%, FS + IC was 86.06%, FS + IC + RICC was 92.68%. The retrospective study demonstrated the diagnostic accuracy of FS was 79.76%, FS + IC was 87.33% and FS + IC + RICC was 92.68%. The positive predictive value, negative predictive value, sensitivity, specificity and accuracy of CD20 were 100%, 76.92%, 90.32%, 100% and 92.68%, respectively. The results of the paired χ 2  test was no statistically significant difference (0.05 < P < 0.1) between FS + IC + RICC and immunohistochemical (IHC) diagnosis of paraffin sections. The integration of IC + RICC + FS diagnosis can significantly enhance the intraoperative diagnostic accuracy of PCNSL and rectify potential errors that may occurred when relying solely on FS diagnosis.
(© 2024. The Author(s).)
Databáze: MEDLINE
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