Olfactory Neuroblastoma and Olfactory Carcinoma: A Practical Review.
| Autor: | Mikula MW; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA., Rooper LM; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: rooper@jhmi.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Surgical pathology clinics [Surg Pathol Clin] 2024 Dec; Vol. 17 (4), pp. 637-652. Date of Electronic Publication: 2024 Aug 24. |
| DOI: | 10.1016/j.path.2024.07.010 |
| Abstrakt: | In the sinonasal tract, two tumor types are defined by neuroectodermal differentiation. Olfactory neuroblastoma (ONB), the traditional member of this category, is a keratin-negative neuroectodermal neoplasm that has lobulated architecture and variable neurofibrillary matrix. Olfactory carcinoma (OC), a newly-recognized diagnosis in the sinonasal tract, has keratin-positive neuroectodermal elements frequently intermixed with well-formed glands. These two neuroectodermal entities can show substantial overlap with other sinonasal small round blue cell tumors that express neuroendocrine markers. This review provides a practical overview of the key clinical and diagnostic features of ONB and OC and their differential diagnosis. Competing Interests: Disclosure The authors have nothing to disclose. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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