Mucoadhesion across scales: Towards the design of protein-based adhesives.

Autor: Hazt B; Food Colloids and Bioprocessing Group, School of Food Science and Nutrition, University of Leeds, LS2 9JT, UK., Read DJ; School of Mathematics, University of Leeds, LS2 9JT, UK., Harlen OG; School of Mathematics, University of Leeds, LS2 9JT, UK., Poon WCK; School of Physics and Astronomy, University of Edinburgh, Peter Guthrie Tait Road, Edinburgh EH9 3FD, UK., O'Connell A; Polymer Science Platform, Reckitt Benckiser Healthcare (UK) Ltd, Dansom Lane S, Hull, HU8 7DS, UK., Sarkar A; Food Colloids and Bioprocessing Group, School of Food Science and Nutrition, University of Leeds, LS2 9JT, UK. Electronic address: A.Sarkar@leeds.ac.uk.
Jazyk: angličtina
Zdroj: Advances in colloid and interface science [Adv Colloid Interface Sci] 2024 Dec; Vol. 334, pp. 103322. Date of Electronic Publication: 2024 Oct 26.
DOI: 10.1016/j.cis.2024.103322
Abstrakt: Mucoadhesion is a special case of bioadhesion in which a material adheres to soft mucosal tissues. This review elucidates our current understanding of mucoadhesion across length, time, and energy scales by focusing on relevant structural features of mucus. We highlight the importance of both covalent and non-covalent interactions that can be tailored to maximize mucoadhesive interactions, particularly concerning proteinaceous mucoadhesives, which have been explored only to a limited extent so far in the literature. In particular, we highlight the importance of thiol groups, hydrophobic moieties, and charged species inherent to proteins as key levers to fine tune mucoadhesive performance. Some aspects of protein surface modification by grafting specific functional groups or coupling with polysaccharides to influence mucoadhesive performance are examined. Insights from this review offer a physicochemical roadmap to inform the development of biocompatible, protein-based mucoadhesive systems that can fulfil dual roles for both adhesion and delivery of actives, enabling the fabrication of advanced biomedical, nutritional and allied soft material technologies.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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