Further evidence for the association between childhood trauma and suicidal ideation in young individuals: A twin based study.
Autor: | Moreno-Gamazo N; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain., Pries LK; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Fac. Health, Medicine and Life Sciences, 6200MD Maastricht, the Netherlands., Marqués-Feixa L; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain; Biomedicine Institute of the University of Barcelona (IBUB), 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, Spain., Papiol S; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, Spain; Dept. Falkai, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Romero S; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, Spain; Department of Child and Adolescent Pychiatry and Psychology, Institut Clínic de Neurociències, Hospital Clínic Universitari, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Barcelona, Spain., Menne-Lothmann C; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Fac. Health, Medicine and Life Sciences, 6200MD Maastricht, the Netherlands., Decoster J; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Fac. Health, Medicine and Life Sciences, 6200MD Maastricht, the Netherlands; Department of Neurosciences, University Psychiatric Centre KU Leuven, 3000 Leuven, Belgium; Brothers of Charity, University Psychiatric Centre Sint-Kamillus Bierbeek, 3360 Bierbeek, Belgium., van Winkel R; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Fac. Health, Medicine and Life Sciences, 6200MD Maastricht, the Netherlands; Department of Neurosciences, University Psychiatric Centre KU Leuven, 3000 Leuven, Belgium., Collip D; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Fac. Health, Medicine and Life Sciences, 6200MD Maastricht, the Netherlands., Delespaul P; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Fac. Health, Medicine and Life Sciences, 6200MD Maastricht, the Netherlands., De Hert M; Department of Neurosciences, University Psychiatric Centre KU Leuven, 3000 Leuven, Belgium., Derom C; Centre of Human Genetics, University Hospitals Leuven, KU Leuven, 3000 Leuven, Belgium; Department of Obstetrics and Gynecology, Ghent University Hospitals, Ghent University, 9000 Ghent, Belgium., Thiery E; Department of Neurology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium., Jacobs N; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Fac. Health, Medicine and Life Sciences, 6200MD Maastricht, the Netherlands; Faculty of Psychology and Educational Sciences, Open University of the Netherlands, 6419 AT Heerlen, the Netherlands., Wichers M; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Fac. Health, Medicine and Life Sciences, 6200MD Maastricht, the Netherlands; Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, 9700 AD Groningen, the Netherlands., van Os J; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Fac. Health, Medicine and Life Sciences, 6200MD Maastricht, the Netherlands; Department of Psychiatry, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, 3584, CX, Utrecht, the Netherlands; Department of Psychosis Studies, Institute of Psychiatry, King's Health Partners, King's College London, London SE5 8AF, UK., Rutten BPF; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Fac. Health, Medicine and Life Sciences, 6200MD Maastricht, the Netherlands., Fañanás L; Department of Evolutionary Biology, Ecology and Environmental Sciences, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain; Biomedicine Institute of the University of Barcelona (IBUB), 08028 Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, 28029 Madrid, Spain. Electronic address: lfananas@ub.edu., Guloksuz S; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Fac. Health, Medicine and Life Sciences, 6200MD Maastricht, the Netherlands; Department of Psychiatry, Yale School of Medicine, New Haven, CT 06511, USA. Electronic address: sinan.guloksuz@maastrichtuniversity.nl. |
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Jazyk: | angličtina |
Zdroj: | Journal of affective disorders [J Affect Disord] 2025 Feb 01; Vol. 370, pp. 118-123. Date of Electronic Publication: 2024 Oct 31. |
DOI: | 10.1016/j.jad.2024.10.125 |
Abstrakt: | Background: Suicide is a major cause of death among youth. Childhood trauma (CT) has emerged as a leading environmental risk factor for suicidal ideation (SI). The present study intends to understand the association between CT and SI in a sample of twins, highlighting the relevance of CT per se, regardless of genetic vulnerability. Methods: Data were derived from a general population young twin study, the TwinssCan project (N = 796; mean age = 17.4). Different types of CT (physical, emotional and sexual) were explored with CTQ and SI through SCL-90-R. The discordance within twin-pairs was used to dissect the genetic and CT effects in SI. Results: Total CT and all subdomains were associated with an increased risk for SI. The within-pair differences analysis in monozygotic and dizygotic twins suggested that part of this association is not attributable to genetic predisposition, which points out the relevance of CT itself upon the increase of SI. This result converged with CT subdomain analyses of physical abuse and neglect. Limitations: While within-pair twin analyses control for genetic risk, additional environmental shared and individual characteristics should be controlled for (such as poverty or protective factors). More detailed information on SI would be of great interest to better capture the complexity of this construct. Conclusion: CT appears to be an important environmental risk factor for SI and at least partly independent of Gene-Environment correlation (rGE). This study highlights the importance of including the history of CT in psychiatric evaluations of patients. The burden of the psychosocial environment on SI could be disentangled by further research on environmental risk and protective factors. Competing Interests: Declaration of competing interest The authors declare no conflicts of interest. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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