An Overview of Film-Forming Emulsions for Dermal and Transdermal Drug Delivery.

Autor: Morales-Becerril A; Facultad de Química, Universidad Autónoma del Estado de México, 50120, Toluca, Estado de México, Mexico., Aranda-Lara L; Facultad de Medicina, Universidad Autónoma del Estado de México, 50180, Toluca, Estado de México, Mexico., Isaac-Olive K; Facultad de Medicina, Universidad Autónoma del Estado de México, 50180, Toluca, Estado de México, Mexico., Ramírez-Villalva A; Escuela Profesional en Química Farmacéutica Biológica-INIES, Universidad de Ixtlahuaca, CUI. Ixtlahuaca, San Pedro, 50740, Estado de México, México., Ocampo-García B; Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, 52750, Ocoyoacac, Estado de México, Mexico., Morales-Avila E; Facultad de Química, Universidad Autónoma del Estado de México, 50120, Toluca, Estado de México, Mexico. emoralesav@uaemex.mx.
Jazyk: angličtina
Zdroj: AAPS PharmSciTech [AAPS PharmSciTech] 2024 Nov 01; Vol. 25 (8), pp. 259. Date of Electronic Publication: 2024 Nov 01.
DOI: 10.1208/s12249-024-02942-3
Abstrakt: Drug delivery through the skin is a widely used therapeutic method for the treatment of local dermatologic conditions. Dermal and transdermal methods of drug delivery offer numerous advantages, but some of the most important aspects of drug absorption through the skin need to be considered. Film-forming systems (FFS) represent a new mode of sustained drug delivery that can be used to replace traditional topical formulations such as creams, ointments, pastes, or patches. They are available in various forms, including solutions, gels, and emulsions, and can be categorised as film-forming gels and film-forming emulsions. Film-forming emulsions (FFE) are designed as oil-in-water (O/W) emulsions that form a film with oil droplets encapsulated in a dry polymer matrix, thus maintaining their dispersed nature. They offer several advantages, including improved solubility, bioavailability and chemical stability of lipophilic drugs. In addition, they could improve the penetration and diffusion of drugs through the skin and enhance their absorption at the target site due to the nature of the components used in the formulation. The aim of this review is to provide an up-to-date compilation of the technologies used in film-forming emulsions to support their development and availability on the market as well as the development of new pharmaceutical forms.
(© 2024. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.)
Databáze: MEDLINE
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