In vivo assessment of cone loss and macular perfusion in children with myopia.

Autor: Shen Y; Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China., Ye X; Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China. yexinsarah@163.com.; Bijie Hospital of Zhejiang Provincial People's Hospital, Bijie, Guizhou, China. yexinsarah@163.com., Zhou X; Wenzhou Medical University, Wenzhou, Zhejiang, China., Yu J; Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China., Zhang C; Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China., He S; Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China., Wu J; Hangzhou Medical College, Hangzhou, Zhejiang, China., Guan H; Wenzhou Medical University, Wenzhou, Zhejiang, China., Xu G; Eye & ENT Hospital of Fudan University, Shanghai, China., Shen L; Center for Rehabilitation Medicine, Department of Ophthalmology, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China. slj@mail.eye.ac.cn.; Wenzhou Medical University, Wenzhou, Zhejiang, China. slj@mail.eye.ac.cn.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 02; Vol. 14 (1), pp. 26373. Date of Electronic Publication: 2024 Nov 02.
DOI: 10.1038/s41598-024-78280-y
Abstrakt: This study evaluated cone density (CD) in the macular region and assess macular perfusion in children with varying degrees of myopia. This was a prospective, cross-sectional, observational study. Children underwent confocal scanning laser ophthalmoscopy (cSLO), optical coherence tomography (OCT), and OCT angiography (OCTA) imaging. A built-in software was used to measure mean CD (cells/mm 2 ), retinal vessel density, choriocapillaris perfusion area, and choroidal thickness (CT). The study included 140 eyes from children categorized into four groups: emmetropia (31 eyes), low myopia (44 eyes), moderate myopia (31 eyes), and high myopia (34 eyes). The high myopia group exhibited significantly lower macular CD than the emmetropia group (P < 0.05). Additionally, the high myopia group showed thinner CT and higher choriocapillaris perfusion area in the macular region than the emmetropia group (all P < 0.01). Macular CD was significantly correlated with age, spherical equivalent, axial length, and CT (all P < 0.05). Generalized linear models revealed CT as the independent factor associated with macular CD (Wald χ2 = 9.265, P = 0.002). Children with high myopia demonstrate reduced CD in the macular region, accompanied by reduced CT. These findings may have important implications for future myopia prevention and management strategies.
(© 2024. The Author(s).)
Databáze: MEDLINE
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