Materials design and characterization of injectable and degradable oxidized alginate PANI:PSS hydrogels for photothermal therapy.

Autor: Shin W; Department of Biofibers and Biomaterials Science, Kyungpook National University, Daegu 41566, Republic of Korea; Department of Materials Science and Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Choi HJ; Department of Biofibers and Biomaterials Science, Kyungpook National University, Daegu 41566, Republic of Korea., Kang B; KNU Institute of Basic Sciences and KNU G-LAMP Project Group, Kyungpook National University, Daegu 41566, Republic of Korea., Lee K; KNU Institute of Basic Sciences and KNU G-LAMP Project Group, Kyungpook National University, Daegu 41566, Republic of Korea; Department of Chemistry, Kyungpook National University, Daegu 41566, Republic of Korea; Biomedical Research Institute, Kyungpook National University Hospital, Daegu 41940, Republic of Korea., Choi YS; Department of Carbon and Fiber Composite, Kyungpook National University, Daegu 41566, Republic of Korea., Choi JH; Department of Biofibers and Biomaterials Science, Kyungpook National University, Daegu 41566, Republic of Korea; Department of Carbon and Fiber Composite, Kyungpook National University, Daegu 41566, Republic of Korea., Kim HA; Department of Biofibers and Biomaterials Science, Kyungpook National University, Daegu 41566, Republic of Korea; Department of Carbon and Fiber Composite, Kyungpook National University, Daegu 41566, Republic of Korea., Choi MK; Department of Materials Science and Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea., Chung K; Department of Biofibers and Biomaterials Science, Kyungpook National University, Daegu 41566, Republic of Korea; Department of Carbon and Fiber Composite, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address: kychung@knu.ac.kr.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2025 Jan 01; Vol. 347, pp. 122652. Date of Electronic Publication: 2024 Aug 29.
DOI: 10.1016/j.carbpol.2024.122652
Abstrakt: Photothermal therapy has gained great attention as an alternative candidate for radiation therapy or chemotherapy for cancers. However, photothermal agents for photothermal therapy are generally in the form of nanoparticles that are too small to remain in the target tissue, and therefore, the agents are rather quickly removed from the targeted site. Furthermore, conventional photothermal agents are generally expensive or complicated to synthesize. As an approach to these issues, here we present new hydrogels with oxidized alginate ionically crosslinked with Ca 2+ , bearing polyaniline:poly(sodium 4-styrenesulfonate) (PANI:PSS) nanoparticles in the polymer network. The presented oxidized alginate PANI:PSS hydrogels exhibited excellent injectability as well as a gradual degradation rate from several days to several months depending on the oxidation degree of alginate chains. The presented oxidized alginate PANI:PSS hydrogels showed an excellent photothermal effect even under a neutral pH environment by showing temperature increased to 53 °C in 5 min upon NIR irradiation, which provide strong potential as a candidate for photothermal agent in photothermal therapy.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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