Infectious Morbidity and All-cause Mortality of Infants HIV-exposed Uninfected Compared to Infants HIV-unexposed Uninfected in Botswana.

Autor: Dubois MM; From the Division of Pediatric Infectious Diseases, Weill Cornell Medicine, New York City, New York.; Division of Infectious Diseases, Boston Children's Hospital.; Harvard Medical School.; Department of Pediatric Global Health, Massachusetts General Brigham, Boston, Massachusetts., Jao J; Departments of Pediatrics and Medicine, Northwestern University Feinberg School of Medicine.; Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.; Botswana Harvard Health Partnership, Gaborone, Botswana., Sun S; Departments of Pediatrics and Medicine, Northwestern University Feinberg School of Medicine., Legbedze J; Departments of Pediatrics and Medicine, Northwestern University Feinberg School of Medicine., Schenkel S; Department of Pediatric Global Health, Massachusetts General Brigham, Boston, Massachusetts., Mmasa N; County Durham and Darlington NHS Foundation Trust, Darlington Memorial Hospital, Darlington, United Kingdom., Kgole SW; Botswana Harvard Health Partnership, Gaborone, Botswana., Masasa G; Botswana Harvard Health Partnership, Gaborone, Botswana., Happel AU; Division of Immunology, Department of Pathology.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Iwase SC; Division of Immunology, Department of Pathology.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Haghighat R; Harvard Medical School., Moyo S; Botswana Harvard Health Partnership, Gaborone, Botswana.; Division of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Division of Medical Virology, Department of Pathology, Stellenbosch University, Cape Town, South Africa.; School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa.; School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana., Sharma TS; Division of Infectious Diseases, Boston Children's Hospital.; Harvard Medical School., Edlefsen PT; Fred Hutchinson Cancer Center., Shao D; Fred Hutchinson Cancer Center., Jaspan H; Division of Immunology, Department of Pathology.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Seattle Children's Research Institute.; Department of Pediatrics, School of Medicine and Department of Global Health, School of Public Health, University of Washington, Seattle, Washington., Powis KM; Botswana Harvard Health Partnership, Gaborone, Botswana.; Division of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Division of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
Jazyk: angličtina
Zdroj: The Pediatric infectious disease journal [Pediatr Infect Dis J] 2024 Oct 31. Date of Electronic Publication: 2024 Oct 31.
DOI: 10.1097/INF.0000000000004603
Abstrakt: Some studies have reported increased infectious morbidity and all-cause mortality risk among infants HIV-exposed uninfected compared with infants HIV-unexposed uninfected. In a retrospective analysis of infants enrolled in the Botswana-based Tshilo Dikotla study, we found no difference in the prevalence of infectious hospitalizations or deaths from any cause in the first year of life by perinatal HIV exposure.
Competing Interests: The authors have no conflicts of interest to disclose.
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Databáze: MEDLINE