Stem cell-homing biomimetic hydrogel promotes the repair of osteoporotic bone defects through osteogenic and angiogenic coupling.

Autor: Wei FL; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China.; Department of Orthopaedics, General Hospital of Central Theater Command (Wuhan General Hospital of Guangzhou Command, previously), Wuhan 430030, China., Zhai Y; Basic Medical College, Fourth Military Medical University, Xi'an 710032, China., Wang TF; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China., Zhao JW; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China., Wang CL; Department of Pharmaceutical Analysis, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China., Tang Z; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China., Shen K; Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, China., Wu H; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China., Zheng R; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi 710032, China., Du MR; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China., Heng W; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China., Li XX; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China., Yan XD; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China., Gao QY; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China., Guo Z; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China., Qian JX; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China., Zhou CP; Department of Orthopaedics, Tangdu Hospital, Fourth Military Medical University, 710038 Xi'an, China.
Jazyk: angličtina
Zdroj: Science advances [Sci Adv] 2024 Nov; Vol. 10 (44), pp. eadq6700. Date of Electronic Publication: 2024 Nov 01.
DOI: 10.1126/sciadv.adq6700
Abstrakt: Osteoporotic bone defects refer to the disruption of bone structural integrity in patients with osteoporosis and pose a substantial challenge to orthopedic surgeons. In this study, we developed a biomimetic hydrogel to improve the osteogenic microenvironment and promote stem cell homing. This hydrogel served as a container for S-nitrosoglutathione and Ca 2+ , promoting the release of bioactive nitric oxide (NO) from bone marrow mesenchymal stem cells (BMSCs) and human vascular endothelial cells and activating the NO/cyclic guanosine monophosphate signaling pathway. These changes promote osteogenic and angiogenic couplings. The hydrogel simultaneously recruited BMSCs by conjugating the stem cell homing peptide SKPPGTSS. Using a rat distal femoral defect model, it was demonstrated that this hydrogel can effectively increase the formation of bone tissue and new blood vessels and has immune-regulating functions. We envision that this hydrogel may be a minimally invasive yet highly effective strategy for expediting the healing of osteoporotic bone defects.
Databáze: MEDLINE
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