Customization of neonatal functional magnetic resonance imaging: A preclinical phantom-based study.

Autor: Quinones JF; Psychological Methods and Statistics, Department of Psychology, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.; Cluster of Excellence Hearing4all, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany., Schmitt T; Neuroimaging Unit, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany., Pavan T; Department of Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.; School of Biology and Medicine, University of Lausanne, Lausanne, Switzerland., Hildebrandt A; Psychological Methods and Statistics, Department of Psychology, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.; Cluster of Excellence Hearing4all, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.; Research Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany., Heep A; Research Center Neurosensory Science, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.; Perinatal Neurobiology Group, Department of Pediatrics, School of Medicine and Health Sciences, Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Nov 01; Vol. 19 (11), pp. e0313192. Date of Electronic Publication: 2024 Nov 01 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0313192
Abstrakt: Over the past few decades, the use of functional magnetic resonance imaging (fMRI) on neonates and very young children has increased dramatically in research and clinical settings. However, the specific characteristics of this population and the MRI standards largely derived from adult studies, pose serious practical challenges. The current study aims to provide general methodological guidelines for customized neonatal fMRI by assessing the performance of various fMRI hardware and software applications. Specifically, this article focuses on MR equipment (head coils) and MR sequences (singleband vs. multiband). We computed and compared the signal-to-noise ratio (SNR) and the temporal SNR (tSNR) in different fMRI protocols using a small-size spherical phantom in three different commercial receiver-only head-neck coils. Our findings highlight the importance of coil selection and fMRI sequence planning in optimizing neonatal fMRI. For SNR, the prescan normalize filter resulted in significantly higher values overall, while in general there was no difference between the different sequences. In terms of head coil performance, the 20-channel head coil showed slightly but significantly higher values compared to the others. For tSNR, there was no difference in the usage of the prescan normalize filter, but the values were significantly higher in the singleband EPI sequences compared to the multiband. In contrast to the SNR, the pediatric head coil seems to have an advantage for tSNR. We provide five practical guidelines to assist researchers and clinicians in developing fMRI studies in neonates and young infants. These recommendations are especially relevant considering ethical constraints and exogenous challenges of neonatal fMRI.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Quinones et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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