High correlation of quantitative susceptibility mapping and echo intensity measurements of nigral iron overload in Parkinson's disease.

Autor: Luyken AK; Department of Neurology, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany., Lappe C; Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medical Center Rostock, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Network of Centers of Excellence in Neurodegeneration (CoEN) Center Rostock, Rostock, Germany., Viard R; UAR 2014 - US 41 - PLBS - Plateformes Lilloises en Biologie & Santé, University of Lille, Lille, France.; INSERM, Centre Hospitalier Universitaire (CHU) de Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, LICEND, University of Lille, Lille, France., Löhle M; Department of Neurology, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Network of Centers of Excellence in Neurodegeneration (CoEN) Center Rostock, Rostock, Germany., Kleinlein HR; Department of Neurology, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany., Kuchcinski G; UAR 2014 - US 41 - PLBS - Plateformes Lilloises en Biologie & Santé, University of Lille, Lille, France.; INSERM, Centre Hospitalier Universitaire (CHU) de Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, LICEND, University of Lille, Lille, France.; Department of Neuroradiology, Centre Hospitalier Universitaire (CHU) de Lille, Lille, France., Langner S; Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medical Center Rostock, Rostock, Germany., Wenzel AM; Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medical Center Rostock, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Network of Centers of Excellence in Neurodegeneration (CoEN) Center Rostock, Rostock, Germany., Walter M; Institute of Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, Rostock, Germany., Weber MA; Institute of Diagnostic and Interventional Radiology, Pediatric Radiology and Neuroradiology, University Medical Center Rostock, Rostock, Germany., Storch A; Department of Neurology, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany.; German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Network of Centers of Excellence in Neurodegeneration (CoEN) Center Rostock, Rostock, Germany.; Center for Transdisciplinary Neurosciences Rostock (CTNR), University of Rostock, Rostock, Germany., Devos D; INSERM, Centre Hospitalier Universitaire (CHU) de Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, LICEND, University of Lille, Lille, France.; Neurology and Movement Disorders Department, Reference Center for Parkinson's Disease, Lille Center of Excellence for Neurodegenerative Disorders (LiCEND), Network of Centers of Excellence in Neurodegeneration (CoEN) Center, Centre Hospitalier Universitaire (CHU) de Lille, Lille, France.; Department of Pharmacology, Centre Hospitalier Universitaire (CHU) de Lille, Lille, France., Walter U; Department of Neurology, Rostock University Medical Center, Gehlsheimer Str. 20, 18147, Rostock, Germany. uwe.walter@med.uni-rostock.de.; German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Network of Centers of Excellence in Neurodegeneration (CoEN) Center Rostock, Rostock, Germany. uwe.walter@med.uni-rostock.de.; Center for Transdisciplinary Neurosciences Rostock (CTNR), University of Rostock, Rostock, Germany. uwe.walter@med.uni-rostock.de.
Jazyk: angličtina
Zdroj: Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2024 Nov 01. Date of Electronic Publication: 2024 Nov 01.
DOI: 10.1007/s00702-024-02856-1
Abstrakt: Quantitative susceptibility mapping (QSM) and transcranial sonography (TCS) offer proximal evaluations of iron load in the substantia nigra. Our prospective study aimed to investigate the relationship between QSM and TCS measurements of nigral iron content in patients with Parkinson's disease (PD). In secondary analyses, we wanted to explore the correlation of substantia nigra imaging data with clinical and laboratory findings. Eighteen magnetic resonance imaging and TCS examinations were performed in 15 PD patients at various disease stages. Susceptibility measures of substantia nigra were calculated from referenced QSM maps. Echogenicity of substantia nigra on TCS was measured planimetrically (echogenic area) and by digitized analysis (echo-intensity). Iron-related blood serum parameters were measured. Clinical assessments included the Unified PD Rating Scale and non-motor symptom scales. Substantia nigra susceptibility correlated with echogenic area (Pearson correlation, r = 0.53, p = 0.001) and echo-intensity (r = 0.78, p < 0.001). Individual asymmetry indices correlated between susceptibility and echogenic area measurements (r = 0.50, p = 0.042) and, more clearly, between susceptibility and echo-intensity measurements (r = 0.85, p < 0.001). Substantia nigra susceptibility (individual mean of bilateral measurements) correlated with serum transferrin saturation (Spearman test, r = 0.78, p < 0.001) and, by trend, with serum iron (r = 0.69, p = 0.004). Nigral echogenicity was not clearly related to serum values associated with iron metabolism. Susceptibility and echogenicity measurements were unrelated to PD duration, motor subtype, and severity of motor and non-motor symptoms. The present results support the assumption that iron accumulation is involved in the increase of nigral echogenicity in PD. Nigral echo-intensity probably reflects ferritin-bound iron, e.g. stored in microglia.
(© 2024. The Author(s).)
Databáze: MEDLINE
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