Use of Antibacterial Envelopes in Neuromodulation Surgeries With Implantable Device Insertion: A Systematic Review and Meta-Analysis.

Autor:	de Oliveira HM; Department of Medicine, Federal University of Mato Grosso, Sinop, Mato Grosso, Brazil., Barbosa LM; Department of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Zamora FV; Department of Medicine, State University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil., de Paula BO; Department of Medicine, Federal University of Mato Grosso, Sinop, Mato Grosso, Brazil., de Paula GO; Department of Medicine, Federal University of Mato Grosso, Sinop, Mato Grosso, Brazil., Pilitsis JG; Professor and Chair of the Department of Neurosurgery, University of Arizona, Tucson, Arizona, USA.; Physician Executive for Functional Neurosurgery, Banner Health System, Tucson, Arizona, USA., da Costa PRF; Department of Functional Neurosurgery, Sinedor Clinic, Sinop, Mato Grosso, Brazil.
Jazyk:	angličtina
Zdroj:	Neurosurgery [Neurosurgery] 2024 Nov 01. Date of Electronic Publication: 2024 Nov 01.
DOI:	10.1227/neu.0000000000003242
Abstrakt:	Background and Objectives: Neuromodulation is an advanced therapeutic intervention for managing various neurological, psychiatric, and functional disorders. However, a significant challenge is the risk of infections at the device implantation site. Previous studies have shown that antibacterial envelopes used in cardiovascular surgeries significantly reduce infection risk. It is postulated that similar benefits could occur in neurosurgeries involving implant insertion, but the literature lacks studies analyzing this efficacy. This study aimed to evaluate the effectiveness of antibacterial envelopes in reducing infection rates associated with neuromodulation implants. Methods: We systematically searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials databases up to August 2024 for clinical trials comparing the use of antibacterial impregnated envelopes in patients undergoing neuromodulation-related implant insertion. This study followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Statistical analyses were performed using R version 4.3.2. Risk of bias was assessed using the Risk Of Bias In Nonrandomized Studies-of Interventions tool, and the quality of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation assessment. The study was registered in Prospective Register of Systematic Reviews. Results: Four studies, comprising 1242 patients, were included, of whom 704 (56.7%) received antibacterial envelopes. The pooled analysis showed that the odds of infection were 77% lower in patients using the antibacterial envelope compared with the control group (odds ratios = 0.23; 95% CI = 0.10-0.51; P < .001; I2 = 2%). Conclusion: The use of an antibacterial envelope significantly reduces the odds of infection in patients undergoing neuromodulation-related implant insertion by 77%. These findings underscore the potential of antibacterial envelopes to improve postoperative outcomes. (Copyright © Congress of Neurological Surgeons 2024. All rights reserved.)
Databáze:	MEDLINE
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