The influence of lifestyle and environmental factors on host resilience through a homeostatic skin microbiota: An EAACI Task Force Report.

Autor: Kortekaas Krohn I; Vrije Universiteit Brussel (VUB), Skin Immunology & Immune Tolerance (SKIN) Research Group, Brussels, Belgium.; Vrije Universiteit Brussel (VUB), Department of Dermatology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium., Callewaert C; Faculty of Bioscience Engineering, Ghent University, Centre for Microbial Ecology and Technology (CMET), Ghent, Belgium., Belasri H; Vrije Universiteit Brussel (VUB), Skin Immunology & Immune Tolerance (SKIN) Research Group, Brussels, Belgium.; Vrije Universiteit Brussel (VUB), Department of Dermatology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium., De Pessemier B; Faculty of Bioscience Engineering, Ghent University, Centre for Microbial Ecology and Technology (CMET), Ghent, Belgium., Diez Lopez C; Faculty of Bioscience Engineering, Ghent University, Centre for Microbial Ecology and Technology (CMET), Ghent, Belgium., Mortz CG; Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, Odense, Denmark., O'Mahony L; APC Microbiome Ireland, School of Microbiology, and Department of medicine, University College Cork, Cork, Ireland., Pérez-Gordo M; Departamento de Ciencias Médicas Básicas, Instituto de Medicina Molecular Aplicada (IMMA) Nemesio Díez, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Madrid, Spain., Sokolowska M; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland., Unger Z; Department of Dermatology, University Hospital, Heinrich-Heine University, Duesseldorf, Germany., Untersmayr E; Institute of Pathophysiology and Allergy Research, Centre of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Homey B; Department of Dermatology, University Hospital, Heinrich-Heine University, Duesseldorf, Germany., Gomez-Casado C; Department of Dermatology, University Hospital, Heinrich-Heine University, Duesseldorf, Germany.
Jazyk: angličtina
Zdroj: Allergy [Allergy] 2024 Dec; Vol. 79 (12), pp. 3269-3284. Date of Electronic Publication: 2024 Nov 01.
DOI: 10.1111/all.16378
Abstrakt: Human skin is colonized with skin microbiota that includes commensal bacteria, fungi, arthropods, archaea and viruses. The composition of the microbiota varies at different anatomical locations according to changes in body temperature, pH, humidity/hydration or sebum content. A homeostatic skin microbiota is crucial to maintain epithelial barrier functions, to protect from invading pathogens and to interact with the immune system. Therefore, maintaining homeostasis holds promise to be an achievable goal for microbiome-directed treatment strategies as well as a prophylactic strategy to prevent the development of skin diseases, as dysbiosis or disruption of homeostatic skin microbiota is associated with skin inflammation. A healthy skin microbiome is likely modulated by genetic as well as environmental and lifestyle factors. In this review, we aim to provide a complete overview of the lifestyle and environmental factors that can contribute to maintaining the skin microbiome healthy. Awareness of these factors could be the basis for a prophylactic strategy to prevent the development of skin diseases or to be used as a therapeutic approach.
(© 2024 The Author(s). Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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