Effects of one-night partial sleep deprivation on perivascular space volume fraction: Findings from the Stockholm Sleepy Brain Study.

Autor:	Custer RM; Laboratory of Neuro Imaging (LONI), Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Lynch KM; Laboratory of Neuro Imaging (LONI), Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Barisano G; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Herting MM; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Åkerstedt T; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Psychology, Stockholm University, Stockholm, Sweden., Nilsonne G; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.; Department of Psychology, Stockholm University, Stockholm, Sweden., Ahmadi H; Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA., Choupan J; Laboratory of Neuro Imaging (LONI), Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; NeuroScope Inc., Scarsdale, New York, USA.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 27. Date of Electronic Publication: 2024 Oct 27.
DOI:	10.1101/2024.10.26.620382
Abstrakt:	Increased waste clearance in the brain is thought to occur most readily during late-stage sleep (stage N3). Sleep deprivation disrupts time spent in deeper sleep stages, fragmenting the clearance process. Here, we have utilized the publicly available Stockholm Sleepy Brain Study to investigate whether various sleep-related measures are associated with changes in perivascular space (PVS) volume fraction following a late-night short-sleep experiment. Our sample consisted of 60 participants divided into old (65-75 years) and young (20-30 years) age groups. We found that partial sleep deprivation was not significantly associated with major PVS changes. In the centrum semiovale, we observed an interaction between percentage of total sleep time spent in N3 and sleep deprivation status on PVS volume fraction. In the basal ganglia, we saw an interaction between N2 (both percentage of total sleep time and absolute time in minutes) and sleep deprivation status. However, the significance of these findings did not survive multiple comparisons corrections. This work highlights the need for future longitudinal studies of PVS and sleep, allowing for quantification of within-subject morphological changes occurring in PVS due to patterns of poor sleep. Our findings here provide insight on the impacts that a single night of late-night short-sleep has on the perivascular waste clearance system. Competing Interests: Disclosure Statements Non-financial Disclosure: The perivascular space mapping technology is part of a patent owned by Jeiran Choupan, with no financial interest/conflict.
Databáze:	MEDLINE
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