The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases.

Autor:	Reste M; Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal., Ajazi K; Department of Immunotechnology, Lund University, Lund, Sweden., Sayi-Yazgan A; Department of Molecular Biology and Genetics, Faculty of Science and Letters, Istanbul Technical University, Istanbul, Türkiye.; Department of Life Sciences, Centre for Inflammation Research and Translational Medicine, College of Health and Life Sciences, Brunel University London, Uxbridge, United Kingdom., Jankovic R; Faculty of Medicine, Institute of Pathology, University of Belgrade, Belgrade, Serbia., Bufan B; Department of Microbiology and Immunology, University of Belgrade - Faculty of Pharmacy, Belgrade, Serbia., Brandau S; Experimental and Translational Research, Department of Otorhinolaryngology, University Hospital Essen, Essen, Germany., Bækkevold ES; Department of Pathology, Oslo University Hospital-Rikshospitalet, Oslo, Norway., Petitprez F; Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom., Lindstedt M; Department of Immunotechnology, Lund University, Lund, Sweden., Adema GJ; Radiotherapy & OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, Netherlands., Almeida CR; Institute of Biomedicine (iBiMED), Department of Medical Sciences, University of Aveiro, Aveiro, Portugal.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2024 Oct 11; Vol. 15, pp. 1439413. Date of Electronic Publication: 2024 Oct 11 (Print Publication: 2024).
DOI:	10.3389/fimmu.2024.1439413
Abstrakt:	Tertiary Lymphoid Structures (TLS) are organized aggregates of immune cells such as T cells, B cells, and Dendritic Cells (DCs), as well as fibroblasts, formed postnatally in response to signals from cytokines and chemokines. Central to the function of TLS are DCs, professional antigen-presenting cells (APCs) that coordinate the adaptive immune response, and which can be classified into different subsets, with specific functions, and markers. In this article, we review current data on the contribution of different DC subsets to TLS function in cancer and autoimmunity, two opposite sides of the immune response. Different DC subsets can be found in different tumor types, correlating with cancer prognosis. Moreover, DCs are also present in TLS found in autoimmune and inflammatory conditions, contributing to disease development. Broadly, the presence of DCs in TLS appears to be associated with favorable clinical outcomes in cancer while in autoimmune pathologies these cells are associated with unfavorable prognosis. Therefore, it is important to analyze the complex functions of DCs within TLS in order to enhance our fundamental understanding of immune regulation but also as a possible route to create innovative clinical interventions designed for the specific needs of patients with diverse pathological diseases. Competing Interests: FP is a consultant for SOTIO Biotech. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Reste, Ajazi, Sayi-Yazgan, Jankovic, Bufan, Brandau, Bækkevold, Petitprez, Lindstedt, Adema and Almeida.)
Databáze:	MEDLINE
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