Ningxiang pigderived Enterococcus hirae regulates the inflammatory function and enhances the protection of piglets against ETEC challenge.

Autor:	Zhang L; College of Animal Science and Technology, Hunan Agricultural University, Key Laboratory for Quality Regulation of Livestock and Poultry Products of Hunan Province, Changsha, China.; Yuelushan Laboratory, Changsha, China., Wu Z; College of Animal Science and Technology, Hunan Agricultural University, Key Laboratory for Quality Regulation of Livestock and Poultry Products of Hunan Province, Changsha, China.; Yuelushan Laboratory, Changsha, China., Zhang Z; College of Animal Science and Technology, Hunan Agricultural University, Key Laboratory for Quality Regulation of Livestock and Poultry Products of Hunan Province, Changsha, China., Cai R; College of Animal Science and Technology, Hunan Agricultural University, Key Laboratory for Quality Regulation of Livestock and Poultry Products of Hunan Province, Changsha, China.; Yuelushan Laboratory, Changsha, China., Pang S; College of Animal Science and Technology, Hunan Agricultural University, Key Laboratory for Quality Regulation of Livestock and Poultry Products of Hunan Province, Changsha, China.; Yuelushan Laboratory, Changsha, China., Wang J; College of Animal Science and Technology, Hunan Agricultural University, Key Laboratory for Quality Regulation of Livestock and Poultry Products of Hunan Province, Changsha, China.; Yuelushan Laboratory, Changsha, China., Bao X; Department of General Surgery, No. 924 Hospital of Joint Logistics Support Force of PLA, Guilin, China.
Jazyk:	angličtina
Zdroj:	Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Oct 17; Vol. 14, pp. 1476564. Date of Electronic Publication: 2024 Oct 17 (Print Publication: 2024).
DOI:	10.3389/fcimb.2024.1476564
Abstrakt:	This study investigated the effects of Enterococcus hirae (Eh) derived from Ningxiang pigs on growth performance, diarrhea incidence, and immune responses in ETEC-challenged piglets. The results showed that compared to the CON group, ETEC infection significantly reduced the average daily gain (ADG) and average daily feed intake (ADFI), increased rectal temperature, and resulted in a diarrhea rate of up to 24%. Additionally, ETEC infection significantly increased the spleen index and the expression of inflammatory cytokines in the spleen, serum and intestine, with decreasing serum sIgA and colonic SCFAs of piglets. Compared to the ETEC group, orally Eh significantly increased ADFI in ETEC-infected piglets, reduced the diarrhea rate to 11.53%, reduced the spleen index and the expression of inflammatory cytokines in the spleen, serum and intestine, with decreasing serum sIgA and colonic SCFAs of ETEC-infected piglets. Furthermore, correlation analysis revealed that the levels of SCFAs (particularly acetate) were significantly negatively correlated with the expression levels of inflammatory cytokines in colonic and splenic tissues, suggesting that acetate may be a key metabolite in the anti-inflammatory effects of Eh. These results indicate that Eh can enhance the protection of piglets against ETEC K88 via intestine-acetate-spleen axis, thereby alleviating diarrhea and improving growth performance in piglets. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Zhang, Wu, Zhang, Cai, Pang, Wang and Bao.)
Databáze:	MEDLINE
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