SMYD family in cancer: epigenetic regulation and molecular mechanisms of cancer proliferation, metastasis, and drug resistance.

Autor: Han TS; Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.; Korea University of Science and Technology, Daejeon, 34316, Republic of Korea.; Department of Biological Science, Sungkyunkwan University, Suwon, 16419, Republic of Korea., Kim DS; Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea. kds2465@kribb.re.kr.; Korea University of Science and Technology, Daejeon, 34316, Republic of Korea. kds2465@kribb.re.kr., Son MY; Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea. myson@kribb.re.kr.; Korea University of Science and Technology, Daejeon, 34316, Republic of Korea. myson@kribb.re.kr.; Department of Biological Science, Sungkyunkwan University, Suwon, 16419, Republic of Korea. myson@kribb.re.kr., Cho HS; Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea. chohs@kribb.re.kr.; Korea University of Science and Technology, Daejeon, 34316, Republic of Korea. chohs@kribb.re.kr.; Department of Biological Science, Sungkyunkwan University, Suwon, 16419, Republic of Korea. chohs@kribb.re.kr.
Jazyk: angličtina
Zdroj: Experimental & molecular medicine [Exp Mol Med] 2024 Nov; Vol. 56 (11), pp. 2325-2336. Date of Electronic Publication: 2024 Nov 01.
DOI: 10.1038/s12276-024-01326-8
Abstrakt: Epigenetic modifiers (miRNAs, histone methyltransferases (HMTs)/demethylases, and DNA methyltransferases/demethylases) are associated with cancer proliferation, metastasis, angiogenesis, and drug resistance. Among these modifiers, HMTs are frequently overexpressed in various cancers, and recent studies have increasingly identified these proteins as potential therapeutic targets. In this review, we discuss members of the SET and MYND domain-containing protein (SMYD) family that are topics of extensive research on the histone methylation and nonhistone methylation of cancer-related genes. Various members of the SMYD family play significant roles in cancer proliferation, metastasis, and drug resistance by regulating cancer-specific histone methylation and nonhistone methylation. Thus, the development of specific inhibitors that target SMYD family members may lead to the development of cancer treatments, and combination therapy with various anticancer therapeutic agents may increase treatment efficacy.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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