In vivo models of infection: Large animals - Mini review on human-scale one-stage revision in a porcine osteomyelitis model.

Autor: Henriksen NL; Department of Veterinary- and Animal Sciences, University of Copenhagen, Frederiksberg C, Denmark., Gottlieb H; Department of Orthopaedic Surgery, Herlev Hospital, Herlev, Denmark., Bue M; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Orthopaedic Surgery, Aarhus University Hospital, Denmark., Vittrup S; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark., Jensen LK; Department of Veterinary- and Animal Sciences, University of Copenhagen, Frederiksberg C, Denmark. Electronic address: louise-k@sund.ku.dk.
Jazyk: angličtina
Zdroj: Injury [Injury] 2024 Nov; Vol. 55 Suppl 6, pp. 111842.
DOI: 10.1016/j.injury.2024.111842
Abstrakt: Animal models are essential for orthopedic infectious research. However, only few models are currently able to capture the complex and multidisciplinary treatment approach for osteomyelitis. To replicate treatment situations in their entirety, large animal models are needed, and the most used species are sheep and pigs. Herein, we review a well-characterized and reproducible porcine model of human-scale one-stage revision of implant-associated osteomyelitis that can be used for robust preclinical testing of operative and post-operative interventions. The pros and cons of the model are discussed in the context of existing literature on large animal revision models.
Competing Interests: Declaration of competing interest No conflict of interest by any of the authors.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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