Retrospective evaluation of obstetric processes in patients with Familial Mediterranean Fever's disease: The three years experience of a tertiary rheumatology clinic.

Autor:	Deniz R; University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Department of Rheumatology, İstanbul, Turkey; Marmara University, School of Medicine, Faculty of Health Science, Department of Medical Biology and Genetics, İstanbul, Turkey. Electronic address: dr.rabiadeniz@gmail.com., Deniz F; İstanbul Medipol University School of Medicine, Department of Gynecology and Obstetrics, İstanbul, Turkey., Ekmen ŞA; University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Department of Internal Medicine, İstanbul, Turkey., Sevinç-Özgür D; University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Department of Rheumatology, İstanbul, Turkey., Akkuzu G; University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Department of Rheumatology, İstanbul, Turkey., Karaalioğlu B; University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Department of Rheumatology, İstanbul, Turkey., Yıldırım F; University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Department of Rheumatology, İstanbul, Turkey., İnce B; University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Department of Rheumatology, İstanbul, Turkey., Kalkan K; University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Department of Rheumatology, İstanbul, Turkey., Özköse GG; University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Department of Rheumatology, İstanbul, Turkey., Bes C; University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Department of Rheumatology, İstanbul, Turkey.
Jazyk:	angličtina
Zdroj:	Taiwanese journal of obstetrics & gynecology [Taiwan J Obstet Gynecol] 2024 Nov; Vol. 63 (6), pp. 900-903.
DOI:	10.1016/j.tjog.2024.09.008
Abstrakt:	Objectives: Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease affecting both genders in reproductive age. In this study, we aimed to investigate the relation between FMF and pregnancy on both maternal and fetal aspects. Material and Methods: In this retrospective, single-center, descriptive study we analysed total of 95 pregnancies of 40 FMF patients. Clinical and demographic data were obtained from patients' records. To prevent recall bias, only the last pregnancy of each patient was evaluated for disease activity and use or revision of medications during pregnancy. Results: The median age of the patients at diagnosis was 22 and the first pregnancy age was 26 years. The median duration of FMF at last pregnancy was 8 (0-23) years. Eight (20%) patients had at least 1 pregnancy via assisted reproductive techniques (IVF), while 34 (85%) patients had at least 1 spontaneous pregnancy. While 32 patients were in remission (80%) before pregnancy, 8 were clinically active (20%). Improvement in clinical course and attack frequency during pregnancy was observed in 23 patients (57.5%), stable course in 10 (25.0%), and worsening in 7 (17.5%). The rate of live birth was 70.0%, abortus was 28.9%, preterm labor was 8.1%, pre-eclampsia was 5.0%, and only 1 achondroplasia as congenital fetal abnormality was observed. Conclusion: FMF did not constitute a contraindication for pregnancy. The most important obstetric problems, complications, and negative fetal outcomes in the course of pregnancy are increased IVF requirement, abortion, and cesarean rates. There is no increase in the risk of congenital malformations due to FMF itself or use of colchicine. Competing Interests: Declaration of competing interest No conflict of interest was declared by the authors and the study has not been presented in any platform before. (Copyright © 2024. Published by Elsevier B.V.)
Databáze:	MEDLINE
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