Assessment of pulmonary nodules using [ 18 F]-FDG PET/CT in deep inspiration breath-hold.

Autor: Casallas Cepeda MS; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain. Electronic address: Miquele7@gmail.com., Córtes SS; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Fernández IG; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Rincón JO; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Berenguer LR; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Ardila Manjarrez EJ; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Ardila Mantilla JJ; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Morales VC; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Cruz JG; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Rodríguez DZ; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Hualde AM; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Montalvá Pastor JE; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Lara SÁ; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain., Alonso Farto JC; Nuclear Medicine, Hospital General Universitario Gregorio Marañón, 28097 Madrid, Spain.
Jazyk: angličtina
Zdroj: Revista espanola de medicina nuclear e imagen molecular [Rev Esp Med Nucl Imagen Mol (Engl Ed)] 2024 Oct 29, pp. 500074. Date of Electronic Publication: 2024 Oct 29.
DOI: 10.1016/j.remnie.2024.500074
Abstrakt: The characterization of pulmonary nodules (PN) is a primary indication for [ 18 F]-FDG PET/CT. However, respiratory movements hinder this characterization, especially for PN located in the lower lobes. Various methods have been developed to improve image resolution.
Objective: Our objective was to compare the diagnostic efficacy of [ 18 F]-FDG PET/CT in deep inspiration breath-hold (DIBH) versus free-breathing corrected by software, in the evaluation of PN.
Methods: We prospectively analyzed 51 patients to assess PN using [ 18 F]-FDG PET/CT in DIBH and free-breathing corrected by software. A total of 84 nodules with an average size of 10 mm were analyzed, with pathological anatomy or medical treatment decide by a multidisciplinary tumor board used as reference.
Results: A total of 84 PN were evaluated, comparing those in DIBH versus free-breathing, finding statistically significant differences in SUVmax values P(< 0.05) (mean SUVmax 3.7 in free-breathing vs. 5.33 in DIBH). When analyzed by location in lobes, we did not find statistically significant differences, though there was a trend towards higher SUVmax values in the lower lobes. [ 18 F]-FDG PET/CT in DIBH showed high sensitivity (95%) and negative predictive value (NPV) (92%), indicating it may be a promising tool for PN characterization.
Conclusions: The acquisition of [ 18 F]-FDG PET/CT in DIBH significantly improves the sensitivity and diagnostic efficacy in the assessment of PN. Although no statistically significant differences were found based on location, there is a potential benefit for the lower lobes. These findings could support its use in clinical practice.
Competing Interests: Declaration of competing interest The authors have no conflicts of interest to declare.
(Copyright © 2024. Published by Elsevier España, S.L.U.)
Databáze: MEDLINE
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