Edinburgh postpartum depression scores are associated with vaginal and gut microbiota in pregnancy.

Autor: Nel NH; Department of Food Science and Human Nutrition, Michigan State University, 204 Trout, 469 Wilson Rd, East Lansing, MI 48824, United States of America., Marafie A; College of Human Medicine, Michigan State University, United States of America., Bassis CM; Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, United States of America., Sugino KY; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States of America., Nzerem A; Department of Food Science and Human Nutrition, Michigan State University, 204 Trout, 469 Wilson Rd, East Lansing, MI 48824, United States of America., Knickmeyer RR; Department of Food Science and Human Nutrition, Michigan State University, 204 Trout, 469 Wilson Rd, East Lansing, MI 48824, United States of America., McKee KS; Department of Family Medicine, University of Michigan Medical School, United States of America., Comstock SS; Department of Food Science and Human Nutrition, Michigan State University, 204 Trout, 469 Wilson Rd, East Lansing, MI 48824, United States of America. Electronic address: comsto37@msu.edu.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2024 Oct 29. Date of Electronic Publication: 2024 Oct 29.
DOI: 10.1016/j.jad.2024.10.086
Abstrakt: Background: Prenatal and postpartum depression may be influenced by the composition of host associated microbiomes. As such, the objective of this study was to elucidate the relationship between the human gut or vaginal microbiomes in pregnancy with prenatal or postpartum depression.
Methods: 140 female participants were recruited at their first prenatal visit and completed the Edinburgh Postnatal Depression Scale (EPDS) to screen for depression and anxiety, in addition the EPDS was completed one month postpartum. Vaginal and stool biospecimens were collected in the third trimester, analyzed using 16S rRNA gene sequencing, and assessed for alpha and beta diversity. Individual taxa differences and clustering using the k-medoids algorithm enabled community state type classification.
Results: Participants with higher postpartum EPDS scores had higher species richness and lower abundance of L. crispatus in the vaginal microbiota compared to those with lower EPDS scores. Participants with a higher prenatal EPDS score had lower species richness of the gut microbiome. Participants with a vaginal community state type dominated by L. iners had the highest mean prenatal EPDS scores, whereas postpartum EPDS scores were similar regardless of prenatal vaginal state type.
Limitations: Our small sample size and participant's self-report bias limits generalizability of results.
Conclusions: Depression in the prenatal and postpartum period is associated with the composition and diversity of the gut and vaginal microbiomes in the third trimester of pregnancy. These results provide a foundational understanding of the microbial relationships between maternal health and depression for identifying potential therapeutic treatments.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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