Seasonal mood variation in youth and young adults with bipolar spectrum disorder: A longitudinal prospective analysis.

Autor: Estrada-Prat X; Child and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Department of Child and Adolescent Mental Health, Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain., Romero S; Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, SGR01319, Hospital Clínic de Barcelona, IDIBAPS, CIBERSAM-ISCIII, Barcelona, Spain. Electronic address: sromero@clinic.cat., Borras R; Department of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, SGR01319, Hospital Clínic de Barcelona, IDIBAPS, CIBERSAM-ISCIII, Barcelona, Spain., Merranko J; Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Goldstein T; Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hafeman D; Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Hower H; Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA; Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, USA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA., Yen S; Academic Division of Public Psychiatry, Beth Israel Deaconess Medical Center at Massachusetts Mental Health Center, Department of Psychiatry at Harvard Medical School, Boston, MA, USA., Hunt J; Division of Child and Adolescent Psychiatry, Alpert Medical School of Brown University, Bradley Hospital, Providence, RI, USA., Goldstein B; Centre for Youth Bipolar Disorder, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Departments of Psychiatry and Pharmacology, University of Toronto, Toronto, Ontario, Canada., Ryan N; Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Diler R; Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Strober M; Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, USA., Gill M; Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Birmaher B; Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2024 Oct 29; Vol. 370, pp. 159-167. Date of Electronic Publication: 2024 Oct 29.
DOI: 10.1016/j.jad.2024.10.115
Abstrakt: Objective: To determine whether there are latitude and seasonal differences in the prevalence of mood episodes (depression and mania) in youth and young adults with Bipolar Spectrum Disorder (BD).
Methods: Mood polarity was prospectively evaluated in 413 participants with BD. Participants were enrolled in the Course and Outcome of Bipolar Youth (COBY) study at three sites (University of California Los Angeles-UCLA, Brown University, and the University of Pittsburgh Medical Center-UPMC) and interviewed on average every 7 months for an average of 91.9 months (range: 6-228 months), with a total of 274,123 weekly mood ratings. Associations between light exposure and mood polarity were estimated using generalized linear mixed models with time-varying covariates, considering the latitude and seasonality of the study sites and other potential confounders.
Results: Average age at intake and at last assessment was 12.6 ± 3.3 and 27.2 ± 4.8 years-old, respectively. There were significantly more depressive episodes during winter than during summer, spring, and autumn. Considering latitude, UCLA showed significantly lower prevalence of depressive episodes, and an absence of seasonal pattern of depression, compared to the Brown/UPMC sites. For the entire sample, there were more manic/hypomanic episodes during summer than during winter. However, there were no significant between site seasonal differences in the prevalence of manic/hypomanic episodes.
Conclusions: Depressive episodes are more prevalent during the winter and although less significant, manic/hypomanic episodes during the summer. Awareness and interventions to prevent or ameliorate the effects of seasonal variations in mood changes in BD are warranted.
Competing Interests: Declaration of competing interest Dr. X. Estrada-Prat and Dr. S. Romero received a grant from the Alicia Koplowitz Foundation. Dr. T. Goldstein reports grants from the National Institute of Mental Health (NIMH), The American Foundation for Suicide Prevention (AFSP), University of Pittsburgh Clinical and Translational Science Institute (CTSI) and The Pittsburgh Foundation and royalties from Guilford Press, outside the submitted work. Dr. Birmaher reports grants from NIMH, during the conduct of the study; royalties from Random House, Woltas Kluwer (UpToDate) and Lippincott, Williams & Wilkins, outside of the submitted work. Ms. Hower has received research support from NIMH, and honoraria from the Department of Defense (DOD). Dr. Strober has received research support from NIMH, and support from the Resnick Endowed Chair in Eating Disorders. Dr. Hafeman reports grants from NIMH. Dr. B. Goldstein reports grants from Brain & Behavior Research Foundation, Brain Canada, Canadian Institutes of Health Research, Heart & Stroke Foundation, and the University of Toronto Department of Psychiatry. Dr. Yen has received research support from NIMH, the National Center for Complimentary and Integrative Health (NCCIH), and the AFSP. Dr. Ryan reports grants from NIH and The American Foundation for Suicide Prevention (AFSP). Dr. Diler has received NIMH grants. Dr. Jeffrey Hunt receives support from NIMH and an editorial stipend from John Wiley Publishers. Mr. Roger Borras, Mr. Merranko, Ms. Gill report no financial relationships with commercial interests.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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