Uptake of Risk-Reducing Surgeries in an International Real-World Cohort of Hispanic Women.

Autor:	Chavarri-Guerra Y; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Ferrigno-Guajardo A; Department of Medicine, Yale University School of Medicine, New Haven, CT., Villarreal-Garza C; Centro de Cáncer de Mama, Hospital Zambrano Hellion TecSalud, Tecnológico de Monterrey, Nuevo León, México., Martinez-Cannon BA; Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Abugattas-Saba J; Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru., Fontaine AC; New Mexico Cancer Center, Albuquerque, NM., Horcasitas DJ; New Mexico Cancer Center, Albuquerque, NM., Mora-Alferez P; Instituto Nacional de Enfermedades Neoplásicas, Lima, Peru., Unzeitig GW; Laredo Breast Care, Laredo, TX., Brown S; St Joseph's Hospital, Orange, CA., Mohar-Betancourt A; Instituto Nacional de Cancerología and Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico., Nehoray B; City of Hope National Medical Center, Duarte, CA., Del Toro-Valero A; Instituto Jalisciense de Cancerología, Guadalajara, Mexico., Daneri-Navarro A; Universidad de Guadalajara, Guadalajara, Mexico., Ganschow P; University of Illinois, Chicago, IL., Komenaka I; Maricopa Integrated Health System, Phoenix, AZ., Rodriguez Y; Centro de tratamiento e investigación sobre Cancer Luis Carlos Sarmiento Angulo, Bogota, Colombia., Gutierrez Seymour G; California Northstate University, College of Medicine, Elk Grove, CA., Valdez L; Instituto Nacional de Cancerología and Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico., Blazer KR; City of Hope National Medical Center, Duarte, CA., Ellis S; The University of Kansas Comprehensive Cancer Center, Kansas City, KC., Weitzel JN; The University of Kansas Comprehensive Cancer Center, Kansas City, KC.; Latin American School of Oncology, Sierra Madre, CA.
Jazyk:	angličtina
Zdroj:	JCO global oncology [JCO Glob Oncol] 2024 Oct; Vol. 10, pp. e2400097. Date of Electronic Publication: 2024 Oct 31.
DOI:	10.1200/GO.24.00097
Abstrakt:	Purpose: Women with pathogenic variants (PVs) in breast cancer (BC) and ovarian cancer (OC) associated genes are candidates for cancer risk-reducing strategies. Limited information is available regarding risk-reducing surgeries (RRS) among Hispanics. The aim of this study was to describe the uptake of RRS in an international real-world experience of Hispanic women referred for genetic cancer risk assessment (GCRA) and to identify factors affecting uptake. Methods: Between July 1997 and December 2019, Hispanic women, living in the United States or in Latin America, enrolled in the Clinical Cancer Genomics Community Research Network registry were prospectively included. Demographic characteristics and data regarding RRS were obtained from chart reviews and patient-reported follow-up questionnaires. Median follow-up was 41 months. Results: Among 1,736 Hispanic women referred for GCRA, 27.2% women underwent risk-reducing mastectomy (RRM), 25.5% risk-reducing salpingo-oophorectomy (RRSO) and, 10.7% both surgeries. Among BRCA carriers, rates of RRM and RRSO were 47.6% and 56.7%, respectively. In the multivariate analyses, being a carrier of a BC susceptibility gene (odds ratio [OR], 3.44), personal history of BC (OR, 6.22), living in the US (OR, 3.90), age ≤50 years (OR, 1.68) and, family history of BC (OR, 1.56) were associated with a higher likelihood of undergoing RRM. Carrying an OC susceptibility gene (OR, 6.72) was associated with a higher likelihood of undergoing RRSO. Conclusion: The rate of RRS among Hispanic women is suboptimal. PV carriers, women with personal history of cancer, and those with a family history of cancer were more likely to have RRS, with less uptake outside the US. Understanding personal and systemic factors influencing uptake may enable interventions to increase risk appropriate uptake of RRS.
Databáze:	MEDLINE
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