Plantago boissieri : Phytochemical Assessment, Antioxidant, Anti-inflammatoryand Wound Healing Potential.

Autor: Amin E; Beni Suef University, pharmacognosy, beni-suef, 62514, beni-suef, EGYPT., Abouzeid H; Port Said University, pharmacognosy, port said university, port said, EGYPT., Afifi N; Beni Suef University Faculty of Pharmacy, pharmacognosy, beni-suef, 62514, beni-suef, EGYPT., Aboud HM; Beni Suef University, Department of Pharmaceutics,, beni-suef, beni-suef, 62514, beni-suef, EGYPT., Abd El-Ghafar OAM; Nahda University, Department of Pharmacology and Toxicology,, beni-suef, beni-suef, beni-suef, EGYPT., Alabdulrahim AK; Qassim University, pharmacognosy, saudi, qassim, SAUDI ARABIA., Ahmed HS; Beni-Suef University, pharmacognosy, beni-suef, beni-suef, 62514, beni-suef, EGYPT.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Oct 31, pp. e202401718. Date of Electronic Publication: 2024 Oct 31.
DOI: 10.1002/cbdv.202401718
Abstrakt: Plantago is a large genus under family Plantaginaceae. Plantago species were noted for potent antioxidant, anti-inflammatory and wound healing activities. The current research investigated the potential bioactivities as the metabolic content of Plantagoboisserei extract. Results highlighted the rich content of phenolics (450.93 ± 7.4 mg GAE/g extract) and flavonoids (144.2 ± 3.6 mg RE/g extract). HPLC analysis enabled the detection of 17 phenolic constituents among which ellagic acid was found in highest concentration followed by rutin. P. boisserei exhibited a potent antioxidant activity evidenced by the IC50 values in ABTS and H2O2 assays (10.95 and 10.87 µg/mL, respectively) as well as in TAC assay (67.94 mg AAE/g). The anti-microbial activities revealed a moderate activity against Staphylococcus aureus and Proteus vulgaris. In vitro anti-inflammatory potential indicated a characteristic inhibition against COX-1 and COX-2 enzymes with IC50 62.8 and 14.23 µg/mL, respectively, compared to ibuprofen (IC50 8.07 and 6.58, respectively). Additionally, P. boisserei extract achieved a potent wound healing activity using in vivo rat model, this might be attributed to its high content of flavonoids together with other polyphenolic compounds that have a great free radical scavenging potential. P. boisserei is a promising candidate for more extensive phytochemical and biological exploration.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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