The effect of astaxanthin after varicocele surgery on antioxidant status and semen quality in infertile men: A triple-blind randomized clinical trial.
Autor: | Ayub Mohammed Salih S; Department of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran., Jabarpour M; Department of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran.; Department of Infertility, Shariati Hospital Tehran University of Medical Sciences Tehran Iran., Sedighi Gilani MA; Department of Infertility, Shariati Hospital Tehran University of Medical Sciences Tehran Iran.; Department of Andrology, Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine, ACECR Tehran Iran., Sajadi H; Department of Andrology, Reproductive Biomedicine Research Center Royan Institute for Reproductive Biomedicine, ACECR Tehran Iran., Saedi Marghmaleki M; Department of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran., Shabani Nashtaei M; Department of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran.; Department of Infertility, Shariati Hospital Tehran University of Medical Sciences Tehran Iran., Salem M; Department of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran., Amidi F; Department of Anatomy, School of Medicine Tehran University of Medical Sciences Tehran Iran.; Department of Infertility, Shariati Hospital Tehran University of Medical Sciences Tehran Iran. |
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Jazyk: | angličtina |
Zdroj: | Food science & nutrition [Food Sci Nutr] 2024 Aug 19; Vol. 12 (10), pp. 7977-7988. Date of Electronic Publication: 2024 Aug 19 (Print Publication: 2024). |
DOI: | 10.1002/fsn3.4365 |
Abstrakt: | Varicocele (VC) is widely recognized as a prevalent etiological factor contributing to male infertility. It has been established that the generation of reactive oxygen species (ROS) plays a significant role in the progression and development of VC. Antioxidants may regulate ROS levels in these patients. Astaxanthin (ASX) is a carotenoid compound with notable antioxidant and anti-inflammatory characteristics. The current study postulated that the administration of ASX following varicocelectomy (VCT) could potentially enhance antioxidant status and semen quality in these patients. A total of 40 infertile males with clinical VC and abnormal semen analyses were randomly assigned to take part in the current trial. For 3 months following surgery, the intervention group took ASX (6 mg/day) while the control group received a placebo. After intervention, semen parameters, Competing Interests: The authors declare no conflicts of interest. (© 2024 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC.) |
Databáze: | MEDLINE |
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