| Autor: |
Johnson E; LGC Assure, Lexington, Kentucky, USA., Kilgore M; College of Medicine, Department of Pharmacology and Nutritional Science, University of Kentucky, Lexington, Kentucky, USA., Nuzzo P; College of Medicine, Center on Drug and Alcohol Research, Cannabis Center, University of Kentucky, Lexington, Kentucky, USA., Babalonis S; College of Medicine, Center on Drug and Alcohol Research, Cannabis Center, University of Kentucky, Lexington, Kentucky, USA.; College of Medicine, Department of Behavioral Science, University of Kentucky, Lexington, Kentucky, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Cannabis and cannabinoid research [Cannabis Cannabinoid Res] 2024 Oct 30. Date of Electronic Publication: 2024 Oct 30. |
| DOI: |
10.1089/can.2024.0058 |
| Abstrakt: |
Background: Although the majority of cannabinoid research has focused on delta-9-tetrahydrocannabinol (Δ 9 -THC) and cannabidiol (CBD), there is increasing interest in the therapeutic effects of other phytocannabinoid compounds (i.e., minor cannabinoids), as there is little known about their effects or interaction with CBD. The current study objective was to determine the concentrations of 15 minor cannabinoids in unregulated, over-the-counter CBD products. Methods: A cross-section sample of 80 local and national brands of hemp-derived oil products was purchased both online and in local retail outlets in central Kentucky. Epidiolex® was included as a regulated control. Samples from each product were extracted by solvent extraction and quantified by liquid-chromatography tandem mass-spectrometry. The targeted cannabinoids were: cannabidiolic acid (CBDA), cannabidivarin (CBDV), cannabidivarinic acid, Δ 9 -tetrahydrocannabivarin, Δ 9 -tetrahydrocannabivarinic acid, Δ 9 -tetrahydrocannabinolic acid-A, Δ 8 -tetrahydrocannabinol (Δ 8 -THC), cannabigerol (CBG), cannabigerolic acid, cannabinol (CBN), cannabinolic acid, cannabicyclol (CBL), cannabicyclolic acid, cannabichromene (CBC) and cannabichromenic acid. Results: Among the unregulated products included in this analysis, the most frequently detected minor cannabinoids were CBDV (100% of samples tested), CBG (77%), CBC (72%), CBN (67%), CBL (67%), and CBDA (51%). Δ 8 -THC was not detected in any of the products tested. Concentrations of these cannabinoids varied widely from trace concentrations to several mg/mL (e.g., CBDA: 0.006-12.258 mg/mL). Conclusions: These data indicate CBD products often contain minor cannabinoids, although the array and concentrations of these cannabinoids vary widely across products. The concentrations of these minor cannabinoids are largely absent from product labels, leaving consumers uninformed about product contents. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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