Myocardial infarction augments sleep to limit cardiac inflammation and damage.

Autor: Huynh P; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Hoffmann JD; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, NYC Health and Hospitals/Elmhurst, Elmhurst, Queens, NY, USA., Gerhardt T; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Germany and Berlin Institute of Health, Berlin, Germany., Kiss MG; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zuraikat FM; Center of Excellence for Sleep and Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Division of General Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., Cohen O; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Wolfram C; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Germany and Berlin Institute of Health, Berlin, Germany., Yates AG; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Leunig A; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Heiser M; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gaebel L; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Gianeselli M; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Goswami S; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Khamhoung A; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Downey J; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Yoon S; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chen Z; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Roudko V; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dawson T; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ferreira da Silva J; Center for Genomic Medicine, Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Ameral NJ; Department of Pathology, Harvard Medical School, Boston, MA, USA., Morgenroth-Rebin J; Center for Genomic Medicine, Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., D'Souza D; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Koekkoek LL; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Jacob W; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Munitz J; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lee D; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fullard JF; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., van Leent MMT; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Roussos P; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Center for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kim-Schulze S; Human Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shah N; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kleinstiver BP; Center for Genomic Medicine, Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA., Swirski FK; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Leistner D; Department of Cardiology, Angiology and Intensive Care Medicine, Deutsches Herzzentrum der Charité, Germany and Berlin Institute of Health, Berlin, Germany.; Department of Medicine, Cardiology/Angiology, Goethe University Hospital, Frankfurt, Germany., St-Onge MP; Center of Excellence for Sleep and Circadian Research, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Division of General Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA., McAlpine CS; Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.; Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.
Jazyk: angličtina
Zdroj: Nature [Nature] 2024 Nov; Vol. 635 (8037), pp. 168-177. Date of Electronic Publication: 2024 Oct 30.
DOI: 10.1038/s41586-024-08100-w
Abstrakt: Sleep is integral to cardiovascular health 1,2 . Yet, the circuits that connect cardiovascular pathology and sleep are incompletely understood. It remains unclear whether cardiac injury influences sleep and whether sleep-mediated neural outputs contribute to heart healing and inflammation. Here we report that in humans and mice, monocytes are actively recruited to the brain after myocardial infarction (MI) to augment sleep, which suppresses sympathetic outflow to the heart, limiting inflammation and promoting healing. After MI, microglia rapidly recruit circulating monocytes to the brain's thalamic lateral posterior nucleus (LPN) via the choroid plexus, where they are reprogrammed to generate tumour necrosis factor (TNF). In the thalamic LPN, monocytic TNF engages Tnfrsf1a-expressing glutamatergic neurons to increase slow wave sleep pressure and abundance. Disrupting sleep after MI worsens cardiac function, decreases heart rate variability and causes spontaneous ventricular tachycardia. After MI, disrupting or curtailing sleep by manipulating glutamatergic TNF signalling in the thalamic LPN increases cardiac sympathetic input which signals through the β2-adrenergic receptor of macrophages to promote a chemotactic signature that increases monocyte influx. Poor sleep in the weeks following acute coronary syndrome increases susceptibility to secondary cardiovascular events and reduces the heart's functional recovery. In parallel, insufficient sleep in humans reprogrammes β2-adrenergic receptor-expressing monocytes towards a chemotactic phenotype, enhancing their migratory capacity. Collectively, our data uncover cardiogenic regulation of sleep after heart injury, which restricts cardiac sympathetic input, limiting inflammation and damage.
(© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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