Design and reporting of prebiotic and probiotic clinical trials in the context of diet and the gut microbiome.

Autor: Whelan K; Department of Nutritional Sciences, King's College London, London, UK. kevin.whelan@kcl.ac.uk., Alexander M; Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, USA., Gaiani C; Laboratoire d'Ingenierie des Biomolecules, Université de Lorraine, Nancy, France.; Institut Universitaire de France, Paris, France., Lunken G; Department of Pediatrics, University of British Columbia, Vancouver, Canada., Holmes A; School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia.; Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia., Staudacher HM; Food and Mood Centre, IMPACT Institute, Deakin University, Melbourne, Victoria, Australia., Theis S; BENEO-Institute, Obrigheim, Germany., Marco ML; Department of Food Science and Technology, University of California, Davis, Davis, CA, USA. mmarco@ucdavis.edu.
Jazyk: angličtina
Zdroj: Nature microbiology [Nat Microbiol] 2024 Nov; Vol. 9 (11), pp. 2785-2794. Date of Electronic Publication: 2024 Oct 30.
DOI: 10.1038/s41564-024-01831-6
Abstrakt: Diet is a major determinant of the gastrointestinal microbiome composition and function, yet our understanding of how it impacts the efficacy of prebiotics and probiotics is limited. Here we examine current evidence of dietary influence on prebiotic and probiotic efficacy in human studies, including potential mechanisms. We propose that habitual diet be included as a variable in prebiotic and probiotic intervention studies. This recommendation is based on the potential mechanisms via which diet can affect study outcomes, either directly or through the gut microbiome. We consider the challenges and opportunities of dietary assessment in this context. Lastly, we provide recommendations for the design, conduct and reporting of human clinical trials of prebiotics and probiotics (and other biotic interventions) to account for any effect of diet and nutrition.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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