Behavioral and psychological symptoms and brain volumes in community-dwelling older persons from the Nakayama Study.

Autor: Tachibana A; Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan., Iga JI; Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan. iga.junichi.it@ehime-u.ac.jp., Ozaki T; Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan., Yoshino Y; Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan., Yamazaki K; Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan., Ochi S; Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan., Kawabe K; Department of Child Psychiatry, Ehime University Graduate School of Medicine, Ehime University, Ehime, Japan., Horiuchi F; Department of Child Psychiatry, Ehime University Graduate School of Medicine, Ehime University, Ehime, Japan., Yoshida T; Department of Neuropsychiatry, Matsukaze Hospital, Ehime, Japan., Shimizu H; Department of Psychiatry, Heisei Hospital, Ehime, Japan., Mori T; Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan.; Department of Psychiatry, Heisei Hospital, Ehime, Japan., Tatewaki Y; Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan., Taki Y; Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan., Ninomiya T; Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Ueno SI; Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Oct 30; Vol. 14 (1), pp. 26097. Date of Electronic Publication: 2024 Oct 30.
DOI: 10.1038/s41598-024-77477-5
Abstrakt: The frequency of behavioral and psychological symptoms of dementia (BPSD) is high, and it is a challenge to elucidate its neural substrates underlying their development. In recent years, many findings have been reported on the relationship between BPSD and brain volume in dementia patients. However, the results are not fully conclusive. Furthermore, there have been few population-based studies. Therefore, the relationship between BPSD and brain volume was investigated as an exploratory study. Of the 927 older persons who participated in the fifth Nakayama study, 90 were included in this analysis, consisting of 52 patients with mild cognitive impairment and 38 patients with dementia, with head MRI and the Neuropsychiatric Inventory (NPI) data. Multiple regression analysis was used to examine the association between the total score of each BPSD score on the NPI and brain volume estimated by FreeSurfer. On multivariate adjustment, even after false discovery rate correction, insular cortical volumes decreased significantly as total scores for apathy/indifference increased (p value = 0.002, q-value = 0.01). Similarly, total brain volume decreased significantly as total scores for appetite and eating disturbance increased (p value = 0.03), and parietal, temporal, and hippocampal cortical volumes also decreased significantly as total scores for appetite and eating disturbance increased (all p and q values < 0.05). This study's results suggest that apathy is negatively correlated with insular cortical volume, and that appetite and eating disturbance are also correlated with brain regions, including parietal, temporal, and hippocampal volume in a community-dwelling older population.
(© 2024. The Author(s).)
Databáze: MEDLINE
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