Impact of Punica granatum seeds extract (PSE) on renal and testicular tissues toxicity in mice exposed to iron oxide nanoparticles (IONPs).

Autor: Abd El-Aziz YM; Department of Zoology, Faculty of Science, Port Said University, Port Said, 42526, Egypt. yasminabdelaziz2012@yahoo.com., Alaryani FS; College of Science, Department of Biological Sciences, University of Jeddah, 21589, Jeddah, Saudi Arabia., Aljahdali N; Department of Biological Science, College of Science, King Abdulaziz University, 42742 University Avenues, 21551, Jeddah, Saudi Arabia., Majrashi KA; Biological Sciences Department, College of Science & Arts, King Abdulaziz University, 21911, Rabigh, Saudi Arabia., Albaqami NM; Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia., Khattab MS; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt., Eissa EH; Fish Research Centre, Faculty of Environmental Agricultural Sciences, Arish University, El- Arish, Egypt. sayedhemd@gmail.com., Kari ZA; Department of Agricultural Sciences, Faculty of Agro-Based Industry, Universiti Malaysia Kelantan, Jeli Campus, 17600, Jeli, Kelantan, Malaysia., Abu Almaaty AH; Department of Zoology, Faculty of Science, Port Said University, Port Said, 42526, Egypt.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Oct 30; Vol. 14 (1), pp. 26067. Date of Electronic Publication: 2024 Oct 30.
DOI: 10.1038/s41598-024-74410-8
Abstrakt: Recently, nano-manufactured materials have been used to treat many diseases, such as healing wounds and other modern biological applications. This study investigates the positive effect of Punica granatum seeds extract on kidney and testicular toxicities induced by iron oxide nanoparticles. Forty mice were randomly divided into four groups; the 1st group was the control group. The 2nd group was dosed daily with PSE at 100 g per kg. The 3rd group was dosed with 10 doses of iron oxide nanoparticles at 30 mg/kg b.wt of a mouse per day, 10 times only, then this toxic substance was withdrawn for the rest of the experimental period (30 days). The 4th group was dosed with the same doses as the second and third groups. In this research, we focused on the possibility of using the positive curative effects of PSE, which were estimated at the level of blood chemistry biomarkers, as well as histological and histochemical examinations for the kidney and testis after exposure of mice to iron oxide nanoparticles. These aim to clarify the effect of iron oxide nanoparticles on kidney and testicular morphology and their functions, as well as the potential ameliorative effects of PSE.
(© 2024. The Author(s).)
Databáze: MEDLINE
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