Juvenile hormone inhibits lipogenesis of Spodoptera exigua to response to Bacillus thuringiensis GS57 infection.

Autor: Gao B; Graduate School of Chinese Academy of Agricultural Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China., Ji Y; Graduate School of Chinese Academy of Agricultural Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China., Zhao D; College of Plant Protection, Hebei Agricultural University, Baoding 071001, Hebei, China., Yan Y; Graduate School of Chinese Academy of Agricultural Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China., Zhang L; Graduate School of Chinese Academy of Agricultural Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China., Wu H; Graduate School of Chinese Academy of Agricultural Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China., Xie Y; Graduate School of Chinese Academy of Agricultural Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China., Shi Q; Graduate School of Chinese Academy of Agricultural Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China., Wang Y; Graduate School of Chinese Academy of Agricultural Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China., Guo W; Graduate School of Chinese Academy of Agricultural Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China. Electronic address: guowei05@caas.cn.
Jazyk: angličtina
Zdroj: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2024 Nov; Vol. 205, pp. 106110. Date of Electronic Publication: 2024 Sep 02.
DOI: 10.1016/j.pestbp.2024.106110
Abstrakt: The application of Bacillus thuringiensis (Bt) has brought environmental benefits and delayed resistance development of pests. Most studies focus on the Bt insecticidal activity against pests, however, the molecular mechanism of Bt on impairing the growth and development of Spodoptera exigua remains unknown. Here, we show that juvenile hormone (JH) inhibits the lipogenesis mediated by fatty acid synthases (Fas) of S. exigua in response to Bt infection. The weight and lipid accumulation of S. exigua larvae post Bt infection were less than those of larvae without Bt infection. We further demonstrated that Bt infection causes the JH titer with a significant increase, which downregulates the expression of lipogenesis-related genes, SeFas3, SeFas4, and SeFas5, resulting in the delayed development of S. exigua larvae. In addition, the expression levels of SeFas genes were regulated by SeACC, indicating that SeFas genes were modulated by multiple pathways. Our findings reveal that novel insights into the molecular mechanisms underlying the impaired development caused by Bt infection which can inform the development of strategies for the sustainable pest control in the future.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
Externí odkaz: