Interplay Between Western Diet and Mammary Cancer: Data from a Chemically-induced Model in Wistar Rats.

Autor:	Silva J; Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal; silva_jessy@hotmail.com.; Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), UTAD, Vila Real, Portugal., Azevedo T; Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.; Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), UTAD, Vila Real, Portugal.; Animal and Veterinary Research Centre (CECAV), Associate Laboratory for Animal and Veterinary Science- AL4AnimalS, UTAD, Vila Real, Portugal.; Centro de Investigação de Montanha (CIMO), Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Campus de Santa Apolónia, Bragança, Portugal., Aires I; Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal., Peixoto F; Chemistry Center - Vila Real (CQ-VR), UTAD, Vila Real, Portugal., Neuparth MJ; Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sports - University of Porto (FADEUP), Porto, Portugal.; Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal.; Toxicology Research Unit (TOXRUN), University Institute of Health Sciences, CESPU, Gandra, Portugal., Queiroga FL; Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.; Animal and Veterinary Research Centre (CECAV), Associate Laboratory for Animal and Veterinary Science- AL4AnimalS, UTAD, Vila Real, Portugal., Seixas F; Animal and Veterinary Research Centre (CECAV), Associate Laboratory for Animal and Veterinary Science- AL4AnimalS, UTAD, Vila Real, Portugal., Ferreira R; LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Aveiro, Portugal., Faustino-Rocha AI; Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.; Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), UTAD, Vila Real, Portugal.; Department of Zootechnics, School of Sciences and Technology, University of Évora, Évora, Portugal.; Comprehensive Health Research Center (CHRC), University of Évora, Évora, Portugal., Duarte JA; Associate Laboratory i4HB - Institute for Health and Bioeconomy, University Institute of Health Sciences - CESPU, Gandra, Portugal.; UCIBIO - Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU), Gandra, Portugal., Oliveira PA; Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.; Institute for Innovation, Capacity Building and Sustainability of Agri-food Production (Inov4Agro), UTAD, Vila Real, Portugal.; Department of Veterinary Sciences, UTAD, Vila Real, Portugal.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2024 Nov; Vol. 44 (11), pp. 4843-4856.
DOI:	10.21873/anticanres.17310
Abstrakt:	Background/aim: This study aimed to investigate the influence of Western diet on mammary cancer in Wistar female rats, focusing on systemic responses and tumor development. Materials and Methods: Twenty-eight Wistar female rats were acclimatized and divided into four experimental groups (n=7 each): Western diet (WD), Western diet with N-methyl-N-nitrosourea (MNU) administration (WD+MNU), standard diet (CTR), and standard diet with MNU administration (CTR+MNU). MNU was administered intraperitoneally at 50 mg/kg at seven weeks of age to induce mammary cancer. The 20-week experiment involved monitoring animal weight, food and water intake. At the end of the study, rats were euthanized, and blood samples and organs were collected for hematological and plasma biochemical analysis, oxidative stress, and histo-pathological and immunobiological evaluations of the tumors. Results: No significant differences were found in body weight, composition, or organ weights, but the WD group showed reduced food and water intake and lower cholesterol levels. Leptin and adiponectin levels were higher in the WD+MNU group, suggestive of changes in appetite regulation. Histopathological analysis showed malignant tumors in both MNU-induced groups. However, WD groups had fewer tumors compared to the CTR+MNU group. Conclusion: WD led to higher feed efficiency and increased visceral adipose tissue but decreased systemic cholesterol and triglyceride levels. While this diet resulted in lower tumor incidence, the volume and weight of the tumors were higher. Additionally, the WD decreased ERα and progesterone receptor immunoexpression, while Ki-67 immunoexpression was elevated. (Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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