Effect of infection by Mycoplasma arginini and Mycoplasma salivarium on the oncogenic properties of lung cancer cell line A549.

Autor: Parfenyev SE; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia. Electronic address: gen21eration@gmail.com., Vishnyakov IE; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia., Efimova TN; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia., Daks AA; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia., Shuvalov OY; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia., Fedorova OA; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia., Lomert EV; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia., Tentler DG; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia., Borchsenius SN; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia., Barlev NA; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia; School of Medicine Nazarbayev University, Astana, 010000, Kazakhstan. Electronic address: nikolai.barlev@nu.edu.kz.
Jazyk: angličtina
Zdroj: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Dec 03; Vol. 736, pp. 150878. Date of Electronic Publication: 2024 Oct 23.
DOI: 10.1016/j.bbrc.2024.150878
Abstrakt: Most mycoplasma species are the extracellular parasites affecting different cellular processes including proliferation, cell cycle, protein synthesis, DNA repair and others. Mycoplasma infection was shown to contribute to the pathology of various diseases, including cancer. Upon infection, mycoplasmas typically activate the tumor-associated NF-kB pathway, which is associated with EMT, the main mechanism of metastasis. In this study, we found that two different mycoplasma strains, M. arginini and M. salivarium, promoted the initiation of EMT and simultaneous suppression of the p53 tumor suppressor in A549 lung cancer cells. This led to an increase of cancer cell motility, resistance to the antitumor drug etoposide concomitantly with decreased autophagy. These data indicate that mycoplasmas are able to increase the tumorigenic potential of cancer host cells.
Competing Interests: Declaration of competing interest Parfenyev S.E. - I have nothing to declare. Vishnyakov I.E. - I have nothing to declare. Efimova T.N. Daks A.A. - I have nothing to declare. Shuvalov O.Y. - I have nothing to declare. Fedorova O.A. - I have nothing to declare. Lomert E.V. - I have nothing to declare. Tentler D.G. - I have nothing to declare. Borchsenius S.N. - I have nothing to declare. Barlev N.A. - I have nothing to declare.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: