Tackling water contamination by oncologic drugs: Supported ionic liquids as sustainable adsorbents for cyclophosphamide removal.

Autor: Francisco R; CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal., Monteiro B; CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal; CESAM - Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, 3810-193, Aveiro, Portugal., Santos MJ; CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal., E Silva FA; CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal., Venancio C; CESAM - Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, 3810-193, Aveiro, Portugal., Neves MC; CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal., Lopes I; CESAM - Centre for Environmental and Marine Studies, Department of Biology, University of Aveiro, 3810-193, Aveiro, Portugal., Sousa ACA; Comprehensive Health Research Centre (CHRC) and Department of Biology, School of Science and Technology, University of Évora, 7006-554, Évora, Portugal. Electronic address: acsousa@uevora.pt., Freire MG; CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193, Aveiro, Portugal. Electronic address: maragfreire@ua.pt.
Jazyk: angličtina
Zdroj: Journal of environmental management [J Environ Manage] 2024 Oct 29; Vol. 371, pp. 122995. Date of Electronic Publication: 2024 Oct 29.
DOI: 10.1016/j.jenvman.2024.122995
Abstrakt: Due to the increasing incidence of cancer, the consumption of highly toxic oncological drugs is continuously growing. Given the current lack of efficient technologies to remove/treat these toxic drugs in wastewater treatment plants, the environmental quality is compromised, and aquatic organisms are at risk. To address this critical environmental burden, a new strategy based on supported ionic liquids (SILs) for the simultaneous removal of oncologic drugs and toxicity reduction of aqueous samples is here proposed. Silica-based SILs functionalized with imidazolium-based and quaternary ammonium-based ILs were designed and kinetics and isotherm adsorption studies performed. Aiming to develop an adsorbent able to reduce the toxicity of aqueous samples contaminated with oncological drugs, the toxicity reduction was appraised using the model organism Danio rerio. The obtained results disclose that among the studied SILs, the [Si][N 3888 ]Cl (silica functionalized with propyltrioctylammonium chloride) is the best adsorption material (maximum adsorption capacity, q max  = 67.64 mg g -1 ), with a fast adsorption rate (<20 min). Furthermore, [Si][N 3888 ]Cl was able to remove the toxicity of the treated aqueous samples towards D. rerio embryos, as assessed by lethal and several sublethal endpoints, demonstrating that this material holds remarkable potential for oncological drugs pollution remediation.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: